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Long Story Short - Commercial Success of Cell Cycle Regulators Leading to Broadening Developmental Pipeline
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The Importance of CDKs (Cyclin-dependent kinases)

(Note: companies that could be impacted by the content of this article are listed at the base of the story (desktop version). This article uses third-party references to provide a bullish, bearish and balanced point of view; sources listed in the "Balanced" section) 

Cell proliferation is a tightly regulated process by the cell cycle machinery in normal tissues, while dysregulated cellular proliferation and aberrant proliferation is a hallmark of cancer. Cyclin-dependent kinases (CDKs) are critical regulatory enzymes that drive cell cycle transitions, control cell division and proliferation. Many of the key concepts of CDK biology were discovered over 20 years ago through the study of yeast. In 2001, Doctor Leland H. Hartwell, R. Timothy Hunt and Paul M. Nurse were awarded the Nobel Prize for their discoveries of “key regulators of the cell cycle”.

There are currently >20 members of the CDK family. The cyclin D/cyclin-dependent kinases 4 and 6 (CDK4/6) are regulators of cell cycle and signal through cell cycle pathway involving p16, an endogenous suppressor of CDK4/6, cyclin D1, the regulatory subunit of CDK4/6, and retinoblastoma (Rb) protein, a tumor suppressor. Controlled phosphorylation and deactivation of the Rb protein by the CDK4/6 complex is crucial for the normal cell cycle progression. Unhindered activity of CDK4/6 pathway can result in alterations of cyclin-dependent kinases stimulating cell cycle pathway and cell proliferation in cancer cells. Selective CDK4/6 inhibitors “turn off” these kinases and dephosphorylation of Rb, resulting in a block of cell-cycle progression preventing the proliferation of cancer cells. 

Figure 1. Immune Mechanism in Response to CDK4/6 Inhibitors

Source: AACR 2018


Momentum is building after recent success.

The CDK4 and CDK6 has markedly changed the perception of CDKs as therapeutic targets in cancer. There are currently three selective CDK4/6 inhibitors approved by the U.S. Food and Drug Administration (FDA) for treating hormone receptor–positive breast cancer in combination with hormonal therapy (HR+) HER2 negative (HER2–) metastatic breast cancer (MBC): Pfizer’s palbociclib (Ibrance), Novartis’s ribociclib (Kisqali) and Eli Lilly’s abemaciclib (Verzenio)

All three agents in combination with aromatase inhibitors showed equally effective clinical benefit in overall response rate (ORR), progression free survival (PFS), and a slightly different but near-identical spectrum of adverse events. Ibrance was the first to the market, winning FDA clearance in 2015. In 2018, Ibrance sales reached $4,118 million (90% of the market), while sales of Kisqali and Verzenio were $235 million and $255 million, respectively. The clinical and commercial success of CDK4/6 inhibitors in metastatic breast cancer have led to the enrichment of the product pipeline with the addition of many other CDK and CDK4/6 inhibitors including:

  1. Lerociclib in non-small cell lung cancer (NSCLC) and breast cancer at Phase 1/2 stage
  2. SEL24 in acute myelogenous leukemia (AML) at Phase 1/2 stage
  3. CYC065 in chronic lymphocytic leukemia (CLL) at Phase 1 stage
  4. SY-1365 in solid tumors at Phase 1 stage
  5. ON 123300 in CDK4/6 overactive tumors at pre-IND stage

Past results are discouraging.

Despite significant efforts to translate scientific knowledge into clinical development of CDK inhibitors, clinical results have been disappointing in the past. Flavopiridol, a first-generation CDK inhibitor, was investigated in more than 60 clinical trials between 1998 and 2014. Flavopiridol did not meet the initial high expectations as it showed minimal clinical benefit in patients. Despite evidence of clinical activity in haematological malignancies, such as chronic lymphocytic leukaemia (CLL, 40% response rate), Phase 3 clinical development was halted in 2012 based on lack of durable response and high disease burden in patients.

The second-generation CDK inhibitors, e.g. AZD5438, have also been extensively studied in the clinic. The efforts to achieve increasing potency and selectivity did not meet expectations. As such, development of second generation CDK inhibitors was terminated. Experts believe the failure of these drugs in the clinic could be due to the following:

  1. Lack of full understanding of the mechanism of action
  2. Poor selective targeting of CDK isoforms
  3. Inappropriate patient selection
  4. Lack of differentiation between healthy and cancerous tissues

Overall positive outlook for CDK inhibitors.

Fundamentally, the cell cycle process and cyclin-dependent kinases (CDKs) are critical regulators of cell replication, migration of survival. Deeper understanding of the biology of CDKs has been instrumental to the development of more potent CDK inhibitors, particularly in regard to determining biomarker and combination strategies. The key points to success include:

  1. specificity of the inhibitors in vivo and in vitro
  2. selection of patients
  3. selection of effective combinational strategies

 

Given the critical roles that CDKs play in multiple aspects of cell biology, CDKs inhibitors as a drug class is perceived as significant cancer therapeutics. The positive clinical data and commercial success of dual CDK4 and CDK6 inhibitors suggest that these candidate medicines could potentially be efficacious in many cancer indications.


Sources:

Asghar et al. “The history and future of targeting cyclin-dependent kinases in cancer therapy” Nat Rev Drug Discov. 2015 February; 14(2): 130–146

Besson et al. “CDK Inhibitors: Cell Cycle Regulators and BeyondDev Cell. 2008 Feb;14(2):159-69

Ameratunga et al. “To cycle or fight - CDK 4/6 inhibitors at the crossroads of anti-cancer immunity” Clinical Cancer Research 2018

www.biomedtracker.com

U.S. Food & Drug Administration


Company Ticker Price Previous Mkt Cap Volume 52wk Range
Onconova Therapeutics Inc.
ONTX (Nasdaq)
$0.58
$0.59 (-0.96%)
$97.74M
3.54M
$0.11 - $3.09
Fundamental Analysis
Rating Refer to Research Report
Syros Pharmaceuticals Inc.
SYRS (NGS)
$12.15
$11.42 (+6.39%)
$555.17M
301.20k
$4.27 - $12.36
Cyclacel Pharmaceuticals Inc.
CYCC (Nasdaq)
$4.53
$4.58 (-1.09%)
$22.02M
210.36k
$3.85 - $19.60
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  Research - CoreCivic, Inc. (CXW) - Suspends Dividend; Evaluating Corporate Structure and Capital Allocation, 06/18/2020
  Research - Kratos Defense & Security (KTOS) - Acquisition Expands Satellite Antenna Capability, 06/17/2020
  Research - Townsquare Media (TSQ) - Digital Shines, But Can The Stock Reflect It?, 06/16/2020
  Research - Ely Gold Royalties (ELYGF) - Laying a Foundation for Growth, 06/16/2020
  Research - Cocrystal Pharma Inc. (COCP) - Cocrystaling to combat viral diseases, Initiating Coverage, 06/16/2020
  Research - Onconova Therapeutics (ONTX) - INSPIRE Study Patients' Genomic Profile at the Baseline, 06/15/2020
  Research - Aurania Resources (AUIAF)(ARU:CA) - Highlights from the Annual Shareholder Meeting, 06/12/2020
  Research - Dyadic (DYAI) - C1 Technology to Produce High-Level and Cost-Effective Biologics to Combat Coronavirus, 06/11/2020
  Research - DLH Holdings (DLHC) - Raising Price Target to $11.00 from $8.25, 06/10/2020
  Research - Great Lakes Dredge & Dock - New Build Program Approved and Fleet Renewal On Horizon., 06/10/2020
  Research - Sierra Metals (SMTS)(SMT:CA) - Getting Back to Normal, 06/10/2020
  Research - Townsquare Media (TSQ) - What Does Getting Current On Its Financial Reporting Mean For The Stock?, 06/10/2020
  Research - Orion Group Holdings (ORN) - Elective Move to Bolster Liquidity. Positive Outlook Intact., 06/09/2020
  Research - Tribune Publishing (TPCO) - Why We Are Raising Our Price Target, 06/08/2020
  Sierra Metals Restarting Operations in Peru and Prepares to Ramp Up to Full Capacity, 06/05/2020
  Research - Comtech Telecommunications Corp. (CMTL) - What Does A Full Quarter of COVID Look Like?, 06/04/2020
  Research - Pyxis Tankers Inc. (PXS) - Solid Quarter, But High 2H2020 Uncertainty, 06/04/2020
  Research - Salem Media (SALM) - A Closer Look; Raising Estimates, 06/03/2020
  Research - FAT Brands Inc. (FAT) - FAT Brands: Multi-brand Franchisor with Multiple Growth Avenues, 06/02/2020
  Research - Cumulus Media Inc. (CMLS) - Why Was The Company Seeking To Lift Foreign Ownership Rules?, 06/02/2020
  Research - Salem Media (SALM) - Why We Are More Optimistic, 06/02/2020
  Research - Energy Fuels (UUUU)(EFR:CA) - Reinforcing its Role in the U.S. Critical Minerals Supply Chain, 06/01/2020
  Research - Cardiff Oncology (CRDF) - Lead Drug Gets Fast Track Designation by FDA, 05/29/2020
  Research - Coeur Mining (CDE) - Increasing 2021 Estimates, 05/29/2020
  Research - Ceapro (CRPOF)(CZO) - Robust Q1 Results With 34 Percent Sales Growth, 05/29/2020
  Research - Euroseas Ltd. (ESEA) - Strong Quarter, But Challenges Ahead, 05/28/2020
  Research - Newrange Gold (NRGOF)(NRG:CA) - Drilling Commences at the Pamlico Project in Nevada, 05/28/2020
  Research - Comtech Telecommunications Corp. (CMTL) - Continues to Solidify NG-911 Offerings with New Acquisition, 05/27/2020
  Research - Ceapro (CRPOF)(CZO) - Potential Therapy for Pulmonary Fibrosis in COVID-19 Patients, 05/27/2020
  Research - Neovasc (NVCN)(NVCN:CA) - Neovasc Removes Financing Overhang, 05/27/2020
  Research - Ely Gold Royalties (ELYGF)(ELY:CA) - Visible Growth Drivers, 05/26/2020
  Research - Genprex Inc. (GNPX) - Emerging as a Leader in Cancer Gene Therapy, 05/26/2020
  Research - Sierra Metals (SMTS)(SMT:CA) - Thinking Big, 05/22/2020
  Research - EuroDry Ltd. (EDRY) - Fine-tuning 2020 EBITDA Estimate. Challenges Ahead, But Outlook Positive., 05/20/2020
  Research - Dyadic International Inc. (DYAI) - Q1 2020: Continue Progressing on Validation of C1 Platform, 05/19/2020
  Research - electroCore (ECOR) - Q1 2020: Progressing Slowly but Steady, 05/19/2020
  Research - EuroDry Ltd. (EDRY) - Challenging Quarter and Near-term Outlook Remains Uncertain, 05/19/2020
  Research - Pangaea Logistics Solutions Ltd. (PANL) - Unique Business Model Tempers Impact of Challenging Market, 05/18/2020
  Research - QuoteMedia (QMCI) - Investing To Accelerate Future Growth, 05/18/2020
  Research - Energy Services of America (ESOA) - Another Tough Quarter But Higher Backlog and PPP Loan are Positives, 05/15/2020
  Research - Helix Biopharma (HBPCF)(HBP:CA) - Phase I Results at ASCO Bode Well for Lead Drug's Prospects, 05/15/2020
  Research - Harte-Hanks Inc. (HHS) - Modest Covid Impact; Encouraging Revenue Opportunities, 05/15/2020
  Research - QuoteMedia (QMCI) - Brushing Off Covid, 05/15/2020
  Research - Onconova Therapeutics Inc. (ONTX) - Q1 2020 Earnings: 2020 Could Be Transformational for Onconova, 05/15/2020
  Research - One Stop Systems Inc. (OSS) - Solid Q1 Results but 2Q to be Impacted by COVID-19, 05/15/2020
  Research - Sierra Metals (SMTS)(SMT:CA) - The Benefits of a Growing Production Profile, 05/15/2020
  Research - Ely Gold Royalties (ELYGF)(ELY:CA) - Building on Momentum, 05/14/2020
  Research - PDS Biotechnology Corp (PDSB) - Q1 Highlighted by Foray into Infectious Diseases Area, 05/14/2020
  Research - Cumulus Media Inc. (CMLS) - Trying To Make A Dash To The Other Side, 05/13/2020
  Research - Gevo, Inc. (GEVO) - Wider Quarterly Loss, But Cost Cuts Are Positive, 05/13/2020
  Research - Information Services (III) - COVID to Impact Rest of 2020; Maintaining Outperform but Lowering Price Target, 05/13/2020
  Research - Vectrus (VEC) - Strong 1Q20 Results, 05/13/2020
  Research - Ceapro (CRPOF)(CZO:CA) - Pursuing Novel Nutraceutical and Biopharmaceutical Markets, 05/12/2020
  Research - Aurania Resources (AUIAF)(ARU:CA) - LiDAR Surveys Yield Valuable Leads, 05/12/2020
  Research - Information Services (III) - First Quarter In-Line but COVID Impacting 2Q, 05/12/2020
  Research - Scorpio Bulkers (SALT) - Bolstering Liquidity Due to Near-term Market Weakness, 05/12/2020
  Research - CoreCivic (CXW) - Dealing With COVID-19 Challenges, 05/11/2020
  Research - Eagle Bulk Shipping (EGLE) - Solid Quarter, But Weakness Ahead Before 2H2020 Recovery, 05/11/2020
  Research - E.W. Scripps Company (SSP) - Encouraging Trends In The Second Quarter, 05/11/2020
  Research - Endeavour Silver (EXK)(EDR:CA) - Signs of Progress With More Work to Do, 05/11/2020
  Research - Great Panther Mining (GPL)(GPR:CA) - Lowering Rating to Market Perform, 05/11/2020
  Research - DLH Holdings Corp. (DLHC) - Post Call Commentary and Updated Models, 05/08/2020
  Research - Genco Shipping & Trading Limited (GNK) - Solid Quarter, But Rough Sledding Ahead Before 2H2020 Recovery, 05/08/2020
  Research - InPlay Oil (IPOOF)(IPO:CA) - Making The Most of a Difficult Situation, 05/08/2020
  Research - Gray Television Inc. (GTN) - Uncharted and Choppy, But Very Capable To Navigate, 05/08/2020
  Research - Entravision Communications Corporation (EVC) - Navigating The Crisis With A Boat Load Of Cash, 05/08/2020
  Research - Kratos Defense & Security (KTOS) - A First Quarter Beat, But Lower Expectations for the Second Quarter, 05/08/2020
  Research - Trovagene (TROV) - New CEO, New Name, Still a Promising Cancer Drug, 05/08/2020
  Research - CoreCivic (CXW) - Solid First Quarter. What's Next?, 05/07/2020
  Research - DLH Holdings Corp. (DLHC) - Beats Top and Bottom Lines; Expect VA-CMOP to be Extended, 05/07/2020
  Research - TherapeuticsMD Inc. (TXMD) - Focusing on Annovera and Imvexxy Commercialization, 05/07/2020
  Research - ACCO Brands Corporation (ACCO) - Post 1Q20 Call Commentary, 05/06/2020
  Research - Great Lakes Dredge & Dock (GLDD) - Exceptional quarter to start the year on a positive note., 05/06/2020
  Research - Sierra Metals (SMTS)(SMT:CA) - Resetting Expectations, 05/06/2020
  Research - Torchlight Energy Resouces Inc. (TRCH) - Coverage Dropped, 05/06/2020
  Research - ACCO Brands Corporation (ACCO) - 1Q20 Met Expectations in Spite of COVID-19, 05/05/2020
  Research - Kelly Services Inc. (KELYA) - Reports First Quarter Results. What Will COVID-19 Impact Be?, 05/05/2020
  Research - Genie Energy Ltd. (GNE) - First Quarter Preview, 05/05/2020
  Research - Energy Fuels (UUUU)(EFR:CA) - Slow but Steady Progress, 05/04/2020
  Research - 1-800-Flowers.com (FLWS) - Can There Be Too Much Of A Good Thing?, 05/01/2020
  Research - One Stop Systems Inc. (OSS) - Building Out Another Revenue Stream, 05/01/2020
  Research - Vectrus (VEC) - Wins Position on $6.4 Billion AFCAP V contract, 05/01/2020
  Research - Newrange Gold (NRGOF)(NRG:CA) - Ready to Break Out, 05/01/2020
  Research - Orion Group Holdings (ORN) - A Strong Start to Year. Only Minor Disruptions So Far Despite COVID-19., 05/01/2020
  Research - Akazoo (SONG) - Unanswered Questions, 05/01/2020
  Research - Orion Group Holdings (ORN) - A Strong Start to Year, But Suspending Guidance Due to COVID-19, 04/30/2020
  Research - Pyxis Tankers Inc. (PXS) - Floating Storage Enhances Refined Product Tanker Outlook, 04/29/2020
  Research - Salem Media (SALM) - All Hands On Deck, 04/29/2020
  Research - Trovagene (TROV) - Lead Drug Shows Potential as KRAS inhibitor in Colorectal Cancer, 04/29/2020
  Research Initiation - Indonesia Energy Corp (INDO) - Positioned To Weather The Storm, 04/27/2020
  Research - Tribune Publishing Company (TPCO) - Did The Virus Accelerate Its Digital Transformation?, 04/27/2020
  Research - Coeur Mining (CDE) - Lowering 2020 Estimates Based on Lower Palmarejo Production Expectations, 04/24/2020
  Research - Entravision Communications Corporation (EVC) - Are Investors Underestimating Its Cash In An Over Levered Industry?, 04/24/2020
  Research - Energy Services of America (ESOA) - Positive Developments Amidst COVID-19 Uncertainty, 04/23/2020
  Research - Great Panther Mining Limited (GPL) - New Leadership Takes the Field, 04/22/2020
  Research - One Stop Systems Inc. (OSS) - Completes $6 Million Convertible Note Raise, 04/22/2020
  Research - PDS Biotechnology Corp (PDSB) - Expanding Product Pipeline into Infectious Diseases, 04/21/2020
  Research - E.W. Scripps Company (SSP) - Quarterly Preview: Riding Through The Storm, 04/20/2020
  Research - ProMIS Neurosciences Inc. (PMN:CA) - Advancing Novel Antibody Therapeutics for Neurodegenerative Diseases, 04/20/2020
  Research - Kelly Services Inc. (KELYA) - Withdraws Guidance; Moving to Market Perform, 04/16/2020
  Research - Sierra Metals (SMTS) - Rising to the Challenge, 04/16/2020
  Research - Comtech Telecommunications Corp. (CMTL) - Early Signs of Business Returning?, 04/15/2020
  Research - Endeavour Silver Corp (EXK) - Lowering 2020 Estimates to Reflect Second Quarter Suspension of Operations in Mexico, 04/15/2020
  Research - Townsquare Media (TSQ) - Quarterly Preview: Unsettling Times, 04/14/2020
  Research - 1-800-Flowers.com (FLWS) - What's Not To Love, 04/14/2020
  Research - One Stop Systems (OSS) - Initiates Expense Reduction and Reorganization Plan, 04/14/2020
  Research - Neovasc Inc. (NVCN) - Two Breakthrough Medical Technologies for Cardiovascular Markets, 04/13/2020
  Research - Aurania Resources Ltd. (ARU:CA) - Planning the Next Campaign, 04/13/2020
  Research - Great Lakes Dredge & Dock (GLDD) - Disappointing News, But Favorable Outlook Intact, 04/13/2020
  Research - Great Panther Mining Limited (GPL) - First Quarter Production Results Modestly Better Than Expected, 04/13/2020
  Research - Coeur Mining (CDE) - Lowering 2020 Estimates to Reflect Suspension of Operations at Palmarejo, 04/08/2020
  Industry Report - Media - Quarterly Review: The Dust Has Yet To Settle, 04/08/2020
  Research - Orion Group Holdings (ORN) - Managing Through Uncertainty, 04/08/2020
  Research - InPlay Oil (IPOOF) - Models updated for lower oil price assumptions, 04/07/2020
  Research - CoreCivic (CXW) - Withdraws Guidance. How Safe is the Dividend?, 04/07/2020
  Industry Report - Metals & Mining: 2020-1Q Review and Outlook, 04/06/2020
  Research - Newrange Gold Corp (NRG:CA) - All the Right Moves, 04/03/2020
  Industry Report - Energy Sector Review and Outlook, 04/02/2020
  Research - ACCO Brands Corporation (ACCO) - The Store is on Sale, 04/02/2020
  Research - Great Panther Mining Limited (GPL) - Positioning Tucano to Reach its Full Potential, 04/02/2020
  Research - Comtech Telecommunications Corp. (CMTL) - Favorable Risk-Reward, Lowering Estimates, Company Withdraws Guidance, 04/01/2020
  Research - Dyadic International Inc. (DYAI) - Q4 2019: Constructive 2019 Leading to a Promising Year Ahead, 04/01/2020
  Research - Great Lakes Dredge & Dock (GLDD) - Volatile Quarter But Favorable Outlook Intact, 04/01/2020
  Research - Sierra Metals (SMTS) - Full Year 2019 Results In Line; SMTS Positioned to Weather Near-Term Challenges, 04/01/2020
  Research - QuoteMedia (QMCI) - Is It Having Trouble With The Smaller Fish While Looking For A Big One?, 03/31/2020
  Research - Ely Gold Royalties (ELY:CA) - A Golden Opportunity to Invest in an Emerging Gold Royalty Company, 03/30/2020
  Research - PDS Biotechnology (PDSB) - Well Funded to Advance Cancer Programs, 03/30/2020
  Research - TherapeuticsMD Inc. (TXMD) - Not Unexpected: 2020 Guidance is Suspended, 03/30/2020
  Research - Dyadic International Inc. (DYAI) - Established Another Partnership in China, 03/30/2020
  Research - electroCore (ECOR) - gammaCore Received Clearance for Prevention of Migraine, 03/30/2020
  Research - One Stop Systems Inc. (OSS) - Can the Good Times Continue in 2020?, 03/27/2020
  Research - Salem Media (SALM) - A Not Surprising Move, 03/27/2020
  Research - Onconova Therapeutics Inc. (ONTX) - Q4 2019 Earnings: INSPIRE Topline Data is on Track for H2 2020, 03/26/2020
  Research - electroCore (ECOR) - Q4 2019 Results: Lagged Commercial Success, 03/25/2020
  Research - Pangaea Logistics Solutions Ltd. (PANL) - Unique Business Model Positive for Uncertainty Ahead, 03/25/2020
  Industry Report - What Is Going On With Gold?, 03/24/2020
  Research - Pangaea Logistics Solutions Ltd. (PANL) - A Strong Quarter. Unique Business Model Helps Offset Uncertainty., 03/24/2020
  Research - Pyxis Tankers Inc. (PXS) - Solid Quarter and Refined Product Tanker Outlook Promising Once Uncertainty Passes., 03/23/2020
  Research - 1-800-Flowers.com (FLWS) - Every Problem Is A Gift, 03/20/2020
  Research - Gevo, Inc. (GEVO) - Supply Agreements Bolster Financing Discussions., 03/19/2020
  Research - InPlay Oil (IPOOF) - Results in line but dark clouds growing, 03/19/2020
  Research - Energy Fuels Inc. (UUUU) - Full Year Loss Greater than Expected Due to Inventory Impairment, 03/18/2020
  Research - Helix Biopharma (HBPCF) - Improved Cash Position Bodes Well for Future Prospects, 03/18/2020
  Research - Orion Group Holdings (ORN) - New Marine Awards Support Current Outlook., 03/18/2020
  Research - Grindrod Shipping (GRIN) - Weaker Operating Results, But 2H2020 Recovery Expected, 03/17/2020
  Research - Townsquare Media Inc (TSQ) - Winded By the Virus, 03/17/2020
  Research - CoreCivic (CXW) - Research Initiation - CoreCivic, Inc.: Leading Provider of Mission Critical Real Estate to Government, 03/16/2020
  Research - Harte-Hanks (HHS) - What Has To Happen To Achieve Its Free Cash Flow Goal?, 03/16/2020
  Research - Genie Energy Ltd. (GNE) - Quarterly results reflect growing pains, 03/13/2020
  Research - Harte-Hanks Inc. (HHS) - Is The Company Out Of The Woods?, 03/13/2020
  Research - Salem Media (SALM) - Can The Positive News Continue?, 03/13/2020
  Research - Information Services (III) - Will the Coronavirus Impact 2020 Results?, 03/12/2020
  Research - Information Services (III) - Solid Ending to the Year, 03/11/2020
  Research - InPlay Oil (IPOOF) - Earnings Preview, 03/11/2020
  Research - Great Panther Mining Limited (GPL) - Company Update Is a Mixed Bag , 03/10/2020
  Research - PDS Biotechnology (PDSB) - Overcoming Limitations of Cancer Vaccines, 03/09/2020
  Research - Eagle Bulk Shipping (EGLE) - Challenging Quarter and Current Environment, But 2H2020 Recovery Likely, 03/06/2020
  Research - Entravision Communications Corporation (EVC) - Why Q4 Doesn't Matter, 03/06/2020
  Research - Comtech Telecommunications Corp. (CMTL) - Our First Coronavirus Victim: What's the Impact Going Forward?, 03/05/2020
  Research - Tribune Publishing Company (TPCO) - Crossing The Digital Divide, 03/05/2020
  Research Report - Comtech Telecommunications Corp. (CMTL) - S-4 Provides Details on Gilat Merger, 03/04/2020
  Research - Vectrus (VEC) - Excellent 2019. Will the Momentum Carry Over into 2020?, 03/04/2020
  Research - Great Lakes Dredge & Dock (GLDD) - New Awards Reinforce Positive Outlook, 03/03/2020
  Research - Orion Group Holdings (ORN) -- Set Up for Positive Year Drives Higher Price Target, 03/02/2020
  Research - E.W. Scripps Company (SSP) - A Political Boost, 03/02/2020
  Research - Gray Television Inc. (GTN) - Why We Are Raising Our Price Target, 02/28/2020
  Research - Orion Group Holdings (ORN) - Better than expected 4Q2019 Results and Positive 2020 EBITDA Guidance, 02/27/2020
  Research - Tribune Publishing Company (TPCO) - Further Consolidation Appears Likely, 02/27/2020
  Research - Dyadic International Inc. (DYAI) - Progress and Efforts Continues to Validate C1 Platform, 02/26/2020
  Research - Endeavour Silver Corp (EXK) - Lowering Estimates for 2020; Rating Reset to Market Perform, 02/26/2020
  Research - Genco Shipping & Trading Limited (GNK) - Solid Quarter and Expanding Fleet Renewal Program, 02/26/2020
  Research - Euroseas Ltd. (ESEA) - Challenging Market, But 2H2020 Recovery Ahead?, 02/25/2020
  Research - Kratos Defense & Security (KTOS) - Underwhelming 4Q; Is the Future Brighter?, 02/25/2020
  Research - Orion Group Holdings (ORN) - NobleCon 16 Review - 4Q2019 Results Out Shortly, 02/25/2020
  Research - Coeur Mining (CDE) - Focusing on the Real Value Drivers, 02/24/2020
  Research - Cumulus Media Inc. (CMLS) - A Towering Opportunity , 02/24/2020
  Research - Kelly Services Inc. (KELYA) - NobleCon 16 Review, 02/24/2020
  Research - Newrange Gold Corp (NRG:CA) - Additional Ground Is Staked at Pamlico Based on IP Survey Results, 02/24/2020
  Research - Orion Group Holdings (ORN) - Set Up for Positive Year Drives Higher Price Target, 02/24/2020
  Research - Energy Services of America (ESOA) - Lower Revenue But Higher Margins, 02/21/2020
  Research - One Stop Systems Inc. (OSS) - What Does the New CEO Bring to the Table?, 02/21/2020
  Research - TherapeuticsMD (TXMD) - Q4 2019 Earnings: Annovera is Now the Lead Asset in the Sales Bag, 02/21/2020
  Research - 1-800-Flowers.com (FLWS) - Gets Into A Personal Space, 02/20/2020
  Research - Great Lakes Dredge & Dock (GLDD) - Profitability Remains High and 2020 Outlook Robust, 02/20/2020
  Research - Trovagene (TROV) - Lead Drug Shows Efficacy in Difficult to Treat Prostate Cancer Patients, 02/14/2020
  Research - Seanergy (SHIP) - Focus on Weak Cape Market and Upcoming Refinancing, 02/14/2020
  Research - Newrange Gold Corp (NRG:CA) - Striking Gold with District-Scale Projects in Nevada and the Red Lake Region of Ontario, 02/14/2020
  Research - The McClatchy Company (MNI) - What happened?, 02/14/2020
  Research - Kelly Services Inc. (KELYA) - Can the New Growth Plan Work?, 02/14/2020
  Research - EuroDry Ltd. (EDRY) - Solid Quarter and Well Positioned for Expected 2H2020 Recovery, 02/14/2020
  Research - ACCO Brands Corporation (ACCO) - Post 4Q Call Review: Basic Blocking & Tackling, 02/13/2020
  Research - TherapeuticsMD Inc. (TXMD) - Pre-Q4 Overview: Adjusting Our Earnings Estimates, 02/13/2020
  Research - ACCO Brands (ACCO) - ACCO Reports Record Full Year Sales and Adjusted EPS, 02/12/2020
  Research - Energy Fuels (UUUU) - Relief is in Sight, 02/12/2020
  Research - Helix Biopharma - Pioneer in Cancer Therapy Targeting Tumor Microenvironment (TME), 02/12/2020
  Research - Seanergy (SHIP) - Scrubber Program Complete. Adjusting Estimates for Dry Bulk Market Weakness., 02/12/2020
  Research - Grindrod Shipping (GRIN) - Acquisition of IVS Bulk JV Interest Set to Close, 02/11/2020
  Research - InPlay Oil (IPO:CA) - Canadian Producer Is Growing Through The Drill Bit, Even In a Low-Price Environment, 02/11/2020
  Research - Energy Services of America Corp. (ESOA) - Mid-Quarter Update - On Track, 02/10/2020
  Research - DLH Holdings Corp. (DLHC) - Post Call Update; Positive Outlook, Although Waiting Outcome of 3 Major Contracts, 02/07/2020
  Research - Vectrus (VEC) - U.S. Army Determines LOGCAP V Bid Prices Reasonable, Will Proceed with Original Awardees, 02/07/2020
  Research - DLH Holdings Corp. (DLHC) - 1Q20: Solid Start to the Year, 02/06/2020
  Research - Gevo, Inc. (GEVO) - Good to be Green - Initiating Coverage with OUTPERFORM Rating, 02/06/2020
  Research - Akazoo (SONG) - Selective With Its Opportunities For Expansion, 02/05/2020
  Research - Orion Group Holdings (ORN) - Significant Industrial Award Pushes YTD Awards to $87 million, 02/05/2020
  Research - Endeavour Silver (EXK) - Lowering Estimates to Reflect 2020 Production Guidance, 02/04/2020
  Research - TherapeuticsMD (TXMD) - Low-dose Bijuva NDA filed, Approval is Anticipated in Q4 2020<, 02/04/2020
  Industry Report - Noble Capital Markets Biotechnology Industry Overview January 2020, 01/31/2020
  Research - 1-800-Flowers.com (FLWS) - It's Got Mo, 01/31/2020
  Research - Aurania Resources Ltd. (ARU:CA) - Initial Results Inform and Refine Direction of Drilling, 01/31/2020
  Research - Comtech Telecommunications Corp. (CMTL) - Gilat Satellite: A Transformational Acquisition, 01/30/2020
  Research - Genco Shipping & Trading Limited (GNK) - Scrubbers Done, Quarterly Dividend Tempers Weakness, 01/30/2020
  Research - Dyadic International Inc. (DYAI) - C1 Technology’s Potential to Manufacture Candidate Vaccines Against Coronavirus, 01/29/2020
  Research - Great Panther Mining Limited (GPL) - Exploration Activity in Mexico Carries Momentum into 2020, 01/29/2020
  Research - Scorpio Bulkers (SALT) - Weakness Takes A Toll, But Rebound Expected, 01/28/2020
  Research - Trovagene (TROV) - Emerging as a Leader in Race to Develop KRAS Inhibitor, 01/28/2020
  Research - Kratos Defense & Security (KTOS) - Are Recent Headlines a Harbinger of Things to Come?, 01/27/2020
  Research - Onconova Therapeutics (ONTX): Partnership dissolves - Greater China is Added Back to Onconova’s Territories, 01/24/2020
  Research - Sierra Metals (SMTS): Fourth Quarter Production Results In Line with Expectations, 01/24/2020
  Research - One Stop Systems Inc. (OSS) - Preliminary 4Q and FY2019 Revenues Top Expectations, 01/23/2020
  Research - Orion Group Holdings (ORN) - New Awards of $18 million Push YTD Awards to $40 million., 01/22/2020
  Research - Coeur Mining (CDE): Fourth Quarter Production Results Disappoint; Rating Remains Outperform, 01/21/2020
  Research - Kelly Services Inc. (KELYA) - Latest Acquisition Adds to Educational Services segment, 01/16/2020
  Research - Pyxis Tankers (PXS) - Delta MR Tanker Sale Closed, 01/16/2020
  Research - Great Panther Mining Limited (GPL) - Upgrading to Outperform Based on Improving Risk and Reward Profile, 01/15/2020
  Research - Orion Group Holdings (ORN) - New Concrete Awards Help Near-term Visibility, 01/15/2020
  Research - Endeavor Silver (EXK): Guanacevi and Bolanitos Mines Expected to Drive 2020 Production Growth, 01/13/2020
  Research - Cumulus Media (CMLS): Business As Usual, 01/10/2020
  Industry Report - Media - The Internet Takes Over The World, 01/09/2020
  Research - Grindrod Shipping (GRIN): Dry Bulker with Tanker Upside - Launching Coverage with Outperform, 01/09/2020
  Research - Sierra Metals (SMTS): Plan to Return Capital in 2020 Highlights Confidence in Sustainable Free Cash Flow Growth, 01/09/2020
  Industry Report - Energy - Exploration and Production: 2019 Review and Outlook, 01/08/2020
  Research - Comtech Telecommunications (CMTL) - Troposcatter Award Bigger than We Thought, 01/08/2020
  Research - Dyadic International Inc. (DYAI) - Confidence in 2020 Outlook, 01/08/2020
  Research - Kratos Defense & Security (KTOS) - Additional Contract Wins, 01/08/2020
  Industry Report - Metals & Mining 2019 Review and Outlook, 01/07/2020
  Research - Great Panther Mining Limited (GPL) - Prepayment Agreements Enhance Liquidity and Underscore Operational Confidence, 01/07/2020
  Research - ACCO Brands Corporation (ACCO) - Risk Or Reward Is Favorable, 01/06/2020
  Research - Scorpio Bulkers (SALT): Tanker Investment Helps Offset Weaker Dry Bulk Market, 01/03/2020
  Research - Great Lakes Dredge &amp; Dock (GLDD) - Yearend Awards Total $83 million - Large Potential Awards on Horizon, 01/02/2020
  Research - Kratos Defense & Security (KTOS) - Well Positioned for 2020, 01/02/2020
  Research - Energy Fuels (UUUU) - Is Relief for the Uranium Industry Imminent?, 12/30/2019
  Research - Aurania Resources (ARU:CA) - Making the Most of a Mineral-Rich Project, 12/27/2019
  Research - Onconova Therapeutics (ONTX) - Recent MDS data and what it means for Onconova, 12/27/2019
  Research - E.W. Scripps Company (SSP) - Why Is Scripps Among Our 2020 Favorites?, 12/23/2019
  Research - Sierra Metals (SMTS) - SMTS Updates Yauricocha Mineral and Reserve Estimate, 12/23/2019
  Research - The McClatchy Company (MNI) - A Hopeful Sign For The Equity, 12/20/2019
  Research - Coeur Mining (CDE) - Exploration Efforts to Increase in 2020; Focus on Resource Discovery and Conversion, 12/19/2019
  Research - QuoteMedia (QMCI) - Among Our Candidates For Most Likely To Succeed in 2020, 12/19/2019
  Research - One Stop Systems (OSS) - Price Decline Presents Favorable Risk/Reward Opportunity, 12/18/2019
  Research - ProMis Neuroscience (PMN:CA) - What Does Biogen’s Progress Mean for ProMIS?, 12/18/2019
  Research - DLH Holdings Corp (DLHC): Well Positioned to Capitalize on Government Services Trends, 12/13/2019
  Research - Energy Services of America (ESOA) - Solid Finish to Fiscal Year 2019 and Special Dividend Announced, 12/13/2019
  Research - DLH (DLHC): Another Solid Quarter with Revenue Topping Expectations, 12/12/2019
  Research - Energy Services of America (ESOA) - Launching Coverage. Looking for Solid Finish to Fiscal Year., 12/11/2019
  Research - Salem Media (SALM) - Why The Dividend Cut Should Help The Stock, 12/11/2019
  Research - Coeur Mining (CDE): Increasing 2020 Estimates; Maintaining Outperform Rating, 12/10/2019
  Research - 1-800-Flowers.com (FLWS): Flowers At A Discount, 12/10/2019
  Research - Akazoo (SONG): Music To Our Ears, 12/10/2019
  Research - Great Lakes Dredge & Dock (GLDD): Renewed Confidence in Dredging Market Outlook, 12/10/2019
  Research - Comtech (CMTL) - Strong Q1; Can The Momentum Be Maintained?, 12/05/2019
  Research - QuoteMedia (QMCI) - What Investors Are Looking For, 12/05/2019
  Research - Harte-Hanks (HHS) - New Leadership For A New Phase?, 12/03/2019
  Research - Aurania Resources (ARU:CA) - On the Road to Finding the Lost Cities?, 12/02/2019
  Research - Great Panther Mining Limited (GPL) - GPL Cuts 2019 Production Guidance Again; Lowering Rating to Market Perform, 12/02/2019
  Research - Akazoo (SONG) - Creating A New Vibe On Messaging, 11/27/2019
  Research - Comtech (CMTL) - Satellite Ground Equipment Acquisition, 11/27/2019
  Research - Dyadic (DYAI) - Step Closer to Generating Human-like Proteins with C1 Platform, 11/26/2019
  Research - Euroseas (ESEA) - 3Q2019 Results In Line. Another Acquisition Adds Scale, 11/26/2019
  Research - Information Services (III) - RPA Market Continues to Attract Investors, 11/26/2019
  Research - Aurania Resources (ARU:CA) - Drilling at Yawi is Off to a Good Start, 11/22/2019
  Research - Onconova Therapeutics (ONTX) - What do recent deals mean for Onconova?, 11/22/2019
  Research - Great Lakes Dredge & Dock (GLDD) - Investor Meetings Renew Confidence, 11/21/2019
  Research - Tribune Publishing (TPCO) - What Does A Change In Its Largest Shareholder Mean?, 11/20/2019
  Research - EuroDry (EDRY) Solid Quarter and Balanced Contracting Tempers Volatility, 11/18/2019
  Research - ProMIS Neurosciences (PMN:CA) - Progress Made in Q3 Bodes Well for ProMIS' Prospects, 11/15/2019
  Research - Pyxis Tankers (PXS) - Solid Improvement Likely Extends Into Next Year, 11/15/2019
  Research - Sierra Metals (SMTS) - Higher EBITDA and Operating Cash Flows Driven by Strong Q3 Production, 11/15/2019
  Research - electroCore (ECOR) - Q3 2019: Revising Outlook After Slow Quarter, 11/15/2019
  Research - QuoteMedia (QMCI) - Not Likely To Move The Needle, 11/14/2019
  Research - The McClatchy Company (MNI) - Lots Of Balls In The Air, 11/14/2019
  Research - Dyadic (DYAI) - Q3 2019: Continuing Expansion of C1 Technology Applications, 11/14/2019
  Research - Endeavour Silver (EXK) - Will El Curso Play a Role in Guanacevi's Turnaround?, 11/13/2019
  Research - Genie Energy (GNE) - Boring quarter welcomed after rough 2Q, 11/13/2019
  Research - Harte-Hanks (HHS) - Ahead Of Its Turnaround Plan, 11/13/2019
  Research - Salem Media (SALM) - Addressing The Elephant In The Room, 11/13/2019
  Research - Cumulus Media (CMLS) - Building Value Through Aggressive Debt Reduction, 11/12/2019
  Research - Pangaea Logistics Solutions (PANL) - Unique Business Model Delivers Solid Results, 11/11/2019
  Research - Information Services Group Inc. (III) - Additional 3Q19 Comments; Updated Projections, 11/11/2019
  Research - E.W. Scripps Company (SSP) - What Is At The Core Of Q3 Results?, 11/11/2019
  Research - Trovagene (TROV) - Q3 2019 Results: Trovagene Continues Progressing, 11/11/2019
  Research - Eagle Bulk Shipping (EGLE) - Stock Price Weakness Spells Opportunity, 11/08/2019
  Research - Entravision Communications Corporation (EVC) - What It Can Do To Change The Narrative?, 11/08/2019
  Research - Gray Television (GTN) - Does Q3 Political Indicate a Windfall for 2020, 11/08/2019
  Research - One Stop Systems Inc. (OSS) - Strong 3Q19 Sets Stage for Excellent Full Year 2019, 11/08/2019
  Research - Tribune Publishing Company (TPCO) - Why This Quarter Reflects The Quality Of Its Cash Flow, 11/08/2019
  Research - Genco Shipping (GNK) - Improving Financials and Asset Sales Trigger Special and Regular Dividends, 11/07/2019
  Research - Information Services Group (III) - Mixed Third Quarter Results, But Record Adjusted EBITDA and Strong Cash Generation, 11/07/2019
  Research - Kelly Services Inc. (KELYA) - What Was Behind the Disappointing 3Q19 Results?, 11/07/2019
  Research - Seanergy (SHIP) - 3Q2019 Shortfall Masks Improving Operating Results, 11/07/2019
  Research -Coeur Mining (CDE): Q3 Results Better Than Expected; Increasing Estimates, 11/06/2019
  Research - Endeavour Silver (EXK): Third Quarter In Line With Our Expectations; Lowering 2020 Estimates, 11/06/2019
  Research - Great Lakes Dredge & Dock (GLDD): Backlog rebounded and set up for strong finish to year, 11/06/2019
  Research - Kratos Defense & Security (KTOS): Another Solid Quarter But Will Continuing Resolution Hit The Pause Button?, 11/06/2019
  Research - Townsquare Media (TSQ): Scores Another Good Quarter , 11/06/2019
  Research - Vectrus (VEC): Can Outperformance Continue?, 11/06/2019
  Research - Energy Fuels (UUUU) - No Big Surprises , 11/04/2019
  Research- Great Panther Mining (GPL) - Q3 Falls Short on EPS but Exceeds on EBITDA, 11/01/2019
  Research - Orion Group Holdings (ORN) - On the Right Track. Moving Up Estimates., 11/01/2019
  Research - 1-800-Flowers.com (FLWS) - A Surprisingly Good Harvest, 11/01/2019
  Research - ACCO Brands (ACCO) - Post 3Q19 Conference Call Notes, 10/31/2019
  Research - ORION Group Holdings - Transition Continues with Another Solid Quarter., 10/31/2019
  Research - ACCO Brands (ACCO) - Record 3Q19 Cash Flow; But Top and Bottom Lines Weaker than Expected, 10/30/2019
  Research - Comtech (CMTL) - A Troposcatter Win for Comtech?, 10/30/2019
  Research - Genco Shipping (GNK) - Adjusting Estimates for Updated Scrubber Program Progress, 10/28/2019
  Research - Onconova Therapeutics (ONTX) - Completion of Enrollment is Pushed Back but Data Readout is on Track, 10/25/2019
  Industry Report - Noble Capital Markets Biotechnology Industry Overview, 10/25/2019
  Research - ProMIS Neurosciences (PMN:CA) - Is ProMIS’ Alzheimer’s Antibody Better Than Biogen’s?, 10/24/2019
  Research - Scorpio Bulkers (SALT) - Making A Good Move With Special Dividend, 10/24/2019
  Research - Aurania Resources (ARU:CA) - Full Speed Ahead, 10/23/2019
  Research - Genco Shipping (GNK) - 2H2019 Recovery Intact Despite Recent Weakness, 10/23/2019
  Research - Seanergy (SHIP) - Positive Impact from Dry Bulk Market Firmness, 10/17/2019
  Research - Great Panther Mining Limited (GPL) - GPL Cuts 2019 Production Guidance; Lowering Estimates and Price Target, 10/17/2019
  Research - Sierra Metals (SMTS) - Third Quarter Production Above Expectations; Raising Estimates, 10/17/2019
  Research - Avino Silver & Gold (ASM) - Avino Reports Third Quarter 2019 Production; Dropping Research Coverage, 10/17/2019
  Research Initiation - Akazoo (SONG) - Getting The Company For A Song, 10/16/2019
  Research - Scorpio Bulkers (SALT) - Dry Bulk Market Firmer, But Fine-Tuning 2H2019 Estimates, 10/16/2019
  Research - DLH Holdings Corp. (DLHC) - Announces Preliminary Results for FY19, 10/16/2019
  Research - Coeur Mining (CDE) - Laying the Groundwork for Improved Performance in 2020, 10/14/2019
  Research - Endeavour Silver (EXK) - Still In Turnaround Mode; Visible Path for Improvement, 10/10/2019
  Industry Report - Media - Is The Sell-Off Over?, 10/10/2019
  Industry Report - Energy - Summer's End Brings No Relief For Energy Stocks, 10/08/2019
  Industry Report - Metals & Mining Third Quarter Review and Outlook, 10/07/2019
  Research - Eagle Bulk Shipping (EGLE) - Scrubber Program Change Impacts Estimates, But Outlook Remains Solid, 10/07/2019
  Research - QuoteMedia, Inc. (QMCI) - Could A Bear Market Help This Company?, 10/04/2019
  Research - Great Panther Mining Limited (GPL) - Raising Estimates Based on Improving Outlook, 10/03/2019
  Research - Orion Group Holdings (ORN) - Two Marine Awards Help 2020 Outlook, 10/03/2019
  Research - Great Lakes Dredge & Dock (GLDD) - Total 3Q2019 Awards of $319 million Above Expectations., 10/03/2019
  Research - Great Lakes Dredge & Dock (GLDD) - Two New Jobs - 3Q2019 Awards Likely Above $265 million, 10/02/2019
  Research - electroCore (ECOR) - What Do Recent Developments Mean For electroCore?, 10/02/2019
  Research - Kratos Defense & Security - Risk-Reward Turns Favorable. Upgrading Rating, 10/02/2019
  Research - Euroseas (ESEA) - One Good Contract But Rest of the Fleet Not Following...Yet., 10/01/2019
  Research - Sierra Metals (SMTS) - Looking Ahead to 2020, 10/01/2019
  Research - Trovagene (TROV) - Number of Patients with a Complete Response Increases in AML Study, 10/01/2019
  Research - Great Lakes Dredge & Dock (GLDD) - Backlog Rebound, 09/27/2019
  Research - Kelly Services (KELYA) - What's Next?, 09/27/2019
  Research - TherapeuticsMD (TXMD) - On Track for Annovera Soft Launch, 09/27/2019
  Research - Energy Fuels (UUUU) - Relief on the Horizon?, 09/26/2019
  Research - EuroDry (EDRY) - Moving Estimates Higher, 09/26/2019
  Research - Comtech (CMTL) - Raising PT, 09/25/2019
  Research - Scorpio Bulkers (SALT) - Will Dry Bulk Market Remain Firm?, 09/24/2019
  Research - Endeavor Silver (EXK) - Rating Upgrade, 09/23/2019
  Research - Aurania Resources (ARU.V) - Closed Private Placement, 09/23/2019
  Research - Kratos (KTOS) - Momentum in Unmanned Systems, 09/23/2019
  Research - Orion (ORN) Construction Awards Bolster Outlook, 09/19/2019
  Industry Report - Minerals - Insights from the Precious Metals Summit, 09/16/2019
  Research - Great Lakes Dredge & Dock (GLDD), 09/12/2019
  Industry Report - Biotechnology - Key Catalysts for Oncology Companies, 09/12/2019
  Industry Report - Biotechnology - Success of Cancer Vaccines Approaching?, 09/12/2019
  Research - Eagle Bulk Shipping (EGLE) - Signaling a Recovery, 09/10/2019
  Research - QuoteMedia (QMCI) - A Look Ahead, 09/03/2019
  Research - Aurania Resources (ARU:CA) - Updating Estimates, 08/30/2019
  Research - One Stop Systems (OSS) - ATM Completed, 08/28/2019
  Research - E.W. Scripps (SSP) - Differentiated From Its Peers, 08/28/2019
  Research - Trovagene (TROV) - Progressing Prostate Cancer Data in Small Number of Patients, 08/27/2019
  Research - Aurania Resources (ARU.V) - A Growing Number of Targets, 08/23/2019
  Research - 1-800-Flowers.com (FLWS) - Why this quarter stands out., 08/23/2019
  Reserach - Great Lakes Dredge & Dock (GLDD) - Backlog Rebound Expected, 08/21/2019
  Research - Tribune Publishing (TPCO) - Content to Drive Value, 08/20/2019
  Research - Euroseas (ESEA) -Quarterly Results Stabilizing, 08/19/2019
  Research - EuroDry (EDRY) - Improving Environment, 08/16/2019
  Research - Sierra Metals (SMTS) - Positioned for Improvement, 08/16/2019
  Research - Onconova Therapeutics (ONTX) - Inflection Points Ahead, 08/15/2019
  Research - Dyadic International (DYAI) - Data and Additional Partnerships to Expand Further Value, 08/14/2019
  Research - electroCore (ECOR) - Soothing Investors' Migraine a Bit?, 08/14/2019
  Research - Pangaea Logistics (PANL) - Lower 2Q2019 Shipping Days, But Rebound Ahead, 08/14/2019
  Research - ProMIS Neurosciences (PMN:CA) - Strengthening Drug Portfolio by Adding Novel Alzheimer's Antibodies, 08/14/2019
  Research - QuoteMedia, Inc. (QMCI) - Second Quarter Results Indicate Favorable Momentum, 08/14/2019
  Research - Harte Hanks (HHS) - Substantial Progress Made, 08/13/2019
  Research - Pyxis (PXS) - On Track for Rebound, 08/13/2019
  Research - E.W. Scripps (SSP) - A Surprising Reaction , 08/13/2019
  Research - Salem Media (SALM) - Hitting Fast Forward, 08/13/2019
  Research - Trovagene (TROV) - Inflection Points Later this Year, 08/12/2019
  Research - Endeavor Silver (EXK) - Setting the Stage for Growth, 08/12/2019
  Research - Genco Shipping (GNK) - A Tough Quarter But Rebound Ahead, 08/09/2019
  Research - Avino Silver & Gold (ASM) - Entering the Second Half with Strong Liquidity and Leverage to Higher Commodity Price, 08/09/2019
  Research - Coeur Mining (CDE) - Momentum Building in the Second Half?, 08/09/2019
  Research - One Stop Systems (OSS) - A Solid 2Q Rebound Sets Up the Second Half of 2019, 08/09/2019
  Research - Cumulus Media (CMLS) - Favorable Cash Flow Picture Provides Confidence In Debt Reduction Target, 08/09/2019
  Research - Harte-Hanks (HHS) - With Progress Comes Increased Confidence In Its Turnaround, 08/09/2019
  Research - The McClatchy Company (MNI) - Significant Progress Toward Maintaining Cash Flow, 08/09/2019
  Research - ACCO Brands (ACCO) - New $100 Million Share Repurchase Authorization Continues Capital Return Theme, 08/08/2019
  Research - IEC Electronics (IEC) - Will they really be able to convert this backlog efficiently?, 08/08/2019
  Research - Orion Group Holdings (ORN) - A Construction Award Bolsters Robust Outlook, 08/08/2019
  Research - Kelly Services (KELYA) - Will the Second Half of 2019 Be Better than the First Half?, 08/08/2019
  Research - TherapeuticsMD (TXMD) - Promising Quarter Signaling to a Positive 2H 2019, 08/08/2019
  Research - Tribune Publishing (TPCO) - Another Beat And Raise; Will Investors Take Notice?, 08/08/2019
  Research - Gray Television (GTN) - Advertising Appears Resilient, 08/08/2019
  Research - DLH Corporation (DLHC) - 3Q Post Call Analysis, 08/07/2019
  Research - Seanergy Maritime (SHIP) - Solid Quarter and Strong Start to 2H2019, 08/07/2019
  Industry Report - Biotechnology Overview, 08/07/2019
  Research - Vectrus (VEC) - Today's Investments Will Pay Off Tomorrow, 08/07/2019
  Research - Entravision Communications (EVC) - Will It Make Headway Fixing Digital?, 08/07/2019
  Research - Townsquare Media (TSQ) - Hitting a Nice Stride, 08/07/2019
  Research - Gray Television (GTN) - A Solid Quarter, 08/07/2019
  Research - ACCO Brands (ACCO) - What Will New Acquisition Mean?, 08/06/2019
  Research - DLH Holdings Corp (DLHC) - What Do 3Q19 Results Tell Us About the Combined Company?, 08/06/2019
  Research - Information Services (III) - Will Back Half of Year Be Better Than First Half?, 08/06/2019
  Research - Energy Fuels (UUUU) - Looking Ahead to Working Group Recommendations Expected in October, 08/06/2019
  Research - 1-800-Flowers.com (FLWS) - The Latest Acquisition Is The Berries, 08/06/2019
  Research - Gannett Company (GCI) - Did Gannett Get The Most It Could?, 08/06/2019
  Research - Genie Energy (GNE) - Earnings Miss Causes Decline in Stock, 08/06/2019
  Research - Ducommun (DCO) - Can Momentum in Commercial Aerospace Outlast 737 MAX Headwinds?, 08/06/2019
  Research - Aurania Resources (ARU.V) - Drilling Activity Expected to Accelerate in the Second Half, 08/01/2019
  Research - Prize Mining Corporation (PRZ.V) - Taking Steps to Better Position the Company in the Eyes of Investors, 08/01/2019
  Research - ACCO Brands (ACCO) - A Deeper Dive Into Record 2Q19 Results, 08/01/2019
  Research - Albany International Corp. (AIN) - Woah... Why were aerospace margins so strong this quarter?, 08/01/2019
  Research - Great Lakes Dredge & Dock (GLDD) - Fourth Strong Quarter In A Row. Backlog Rebound Ahead., 08/01/2019
  Research - Orion Group Holdings (ORN) - Rebound Appears Underway Sooner Than Expected, 08/01/2019
  Research - Kratos Defense & Security (KTOS) - Will the Outperformance Continue?, 08/01/2019
  Research - ACCO Brands (ACCO) - Record 2Q Results; What's In-store for the Rest of the Year?, 07/31/2019
  Research - Eagle Bulk Shipping (EGLE) - A Tough Quarter But Set Up for 2H2018 Rebound, 07/30/2019
  Research - Orion Group Holdings (ORN) - Transition Quarter to Strong Second Half Rebound, 07/29/2019
  Research - Eurodry (EDRY) - Positive Impact from Preferred Changes and Recent Dry Bulk Market Rebound., 07/29/2019
  Research - Great Panther Mining Limited (GPL) - Turning the Corner, 07/29/2019
  Research - Kelly Services (KELYA) - Initiating Coverage; A Leading Staffing Company Poised for Additional Growth, 07/29/2019
  Research - Eagle Bulk Shipping (EGLE) - Convert Debt Funds Another Acquisition, Pressures Stock Price, 07/26/2019
  Research - Onconova Therapeutics - Initiation of Coverage, 07/25/2019
  Research - ProMIS Neurosciences (PMN:CA) - Amid Skepticism, Light Will Emerge in Alzheimer's Area, 07/23/2019
  Research - Scorpio Bulkers (SALT) - Worst Has Passed and Rebound Underway, 07/23/2019
  Research - Seanergy Maritime (SHIP) - Cape Market Moving Sharply Higher, SHIP Should Move Up Too, 07/22/2019
  Research - Avino Silver & Gold (ASM) - What is the Expected Impact of Phasing Out San Gonzalo?, 07/19/2019
  Research - Orion Group Holdings (ORN) - Another Project Award Boosts Record Backlog and Reinforces Positive Outlook, 07/18/2019
  Industry Report - Media - Is It Too Early To Bet On Political Advertising?, 07/18/2019
  Research - Sierra Metals (SMTS) - Will the Momentum Continue?, 07/17/2019
  Research - Aurania Resources (ARU.V) - Employing Big Data in the Rainforests of Ecuador, 07/15/2019
  Research - Coeur Mining (CDE) - Will Recent Strength in Gold Prices Benefit Second Half Performance?, 07/15/2019
  Research - Energy Fuels (UUUU) - Section 232 Petition Prompts Working Group for More Study, 07/15/2019
  Research - Endeavour Silver (EXK) - A Work In Progress, 07/11/2019
  Research - Great Panther Mining Limited (GPL) - When Will the Valuation Reflect an Improving Growth Outlook?, 07/11/2019
  Research - QuoteMedia Inc. - Initiation Report, 07/11/2019
  Research - DLH Holdings (DLHC) - An Early Look at the Combined DLH and Social & Scientific Systems, 07/10/2019
  Research - Trovagene (TROV) - What does Colorectal Cancer Trial Add?, 07/10/2019
  Research - Vectrus (VEC) - What does Advantor Systems add to Vectrus?, 07/09/2019
  Research - One Stop Systems (OSS) - What Impact Will the $60 Million OEM Agreement Have?, 07/09/2019
  Research - Dyadic (DYAI) - VTT to Continue Validation of C1 Platform in Bioproduction., 07/08/2019
  Research - Entravision Communications (EVC) - Sheds Light on the Matter, 07/03/2019
  Industry Report - Minerals - Are Mining Stocks Poised for a Better Second Half?, 07/03/2019
  Research - Vectrus (VEC) - Named to Another Contract; Massaging Estimate, 07/02/2019
  Industry Report - Energy - The storage numbers tell it all, 07/02/2019
  Research - Seanergy Maritime (SHIP) - Class C Warrants Expanding Share Count, 07/01/2019
  Research - Prize Mining (PRZ) - Charting a Course for Kena Gold Property, 06/28/2019
  Research - Great Lakes Dredge (GLDD) - More Awards Announced; 2H3019 Backlog Expected, 06/25/2019
  Research - Euroseas (ESEA) - Acquisition and Financing Activity Are Positives, 06/24/2019
  Research - Great Lakes Dredge (GLDD) - Awards Boost Confidence, 06/20/2019
  Research - Endeavour Silver (EXK) - Signs of an Improving Outlook?, 06/19/2019
  Research - TherapeuticsMD (TXMD) - What Investors are Missing, 06/19/2019
  Research - Upgrading the Shares - High Risk but High Upside Potential, 06/17/2019
  Research - Aurania Resources - Lessons from Crunchy Hill, 06/14/2019
  Research - Cumulus Media (CMLS) - Debt Recovery Should Help Stock, 06/13/2019
  Research - DLH Holdings Corp. (DLHC) - Potential Transformative Factors, 06/13/2019
  Research - KeyW Holding (KEYW) - Jacobs Tender Offer Completed, 06/13/2019
  Research - Townsquare Media (TSQ) - Why is the stock below its peers?, 06/11/2019
  Research - electroCore (ECOR) - ECOR Braves Choppy Waters, 06/11/2019
  Research - Comtech (CMTL) - Can the Current Upswing be Maintained?, 06/07/2019
  Research - Comtech (CMTL) - Q3 Delivers Record Backlog, 06/06/2019
  Research - electroCore (ECOR) - Departing Founder and Chief Science and Strategy Officer, 06/05/2019
  Research - Kratos (KTOS) - Price Appreciation Pushes to Market Perform, 06/05/2019
  Research - Aurania Resources (ARU.V) - Copper Exploration Yields Encouraging Results, 05/31/2019
  Research - electroCore (ECOR) - Plans to Remove Headwinds, 05/31/2019
  Research - Euroseas (ESEA) - Price Target Revision, 05/30/2019
  Research - EuroDry (EDRY) - Increasi