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Long Story Short - Commercial Success of Cell Cycle Regulators Leading to Broadening Developmental Pipeline

The Importance of CDKs (Cyclin-dependent kinases)

(Note: companies that could be impacted by the content of this article are listed at the base of the story (desktop version). This article uses third-party references to provide a bullish, bearish and balanced point of view; sources listed in the "Balanced" section) 

Cell proliferation is a tightly regulated process by the cell cycle machinery in normal tissues, while dysregulated cellular proliferation and aberrant proliferation is a hallmark of cancer. Cyclin-dependent kinases (CDKs) are critical regulatory enzymes that drive cell cycle transitions, control cell division and proliferation. Many of the key concepts of CDK biology were discovered over 20 years ago through the study of yeast. In 2001, Doctor Leland H. Hartwell, R. Timothy Hunt and Paul M. Nurse were awarded the Nobel Prize for their discoveries of “key regulators of the cell cycle”.

There are currently >20 members of the CDK family. The cyclin D/cyclin-dependent kinases 4 and 6 (CDK4/6) are regulators of cell cycle and signal through cell cycle pathway involving p16, an endogenous suppressor of CDK4/6, cyclin D1, the regulatory subunit of CDK4/6, and retinoblastoma (Rb) protein, a tumor suppressor. Controlled phosphorylation and deactivation of the Rb protein by the CDK4/6 complex is crucial for the normal cell cycle progression. Unhindered activity of CDK4/6 pathway can result in alterations of cyclin-dependent kinases stimulating cell cycle pathway and cell proliferation in cancer cells. Selective CDK4/6 inhibitors “turn off” these kinases and dephosphorylation of Rb, resulting in a block of cell-cycle progression preventing the proliferation of cancer cells. 

Figure 1. Immune Mechanism in Response to CDK4/6 Inhibitors

Source: AACR 2018


Momentum is building after recent success.

The CDK4 and CDK6 has markedly changed the perception of CDKs as therapeutic targets in cancer. There are currently three selective CDK4/6 inhibitors approved by the U.S. Food and Drug Administration (FDA) for treating hormone receptor–positive breast cancer in combination with hormonal therapy (HR+) HER2 negative (HER2–) metastatic breast cancer (MBC): Pfizer’s palbociclib (Ibrance), Novartis’s ribociclib (Kisqali) and Eli Lilly’s abemaciclib (Verzenio)

All three agents in combination with aromatase inhibitors showed equally effective clinical benefit in overall response rate (ORR), progression free survival (PFS), and a slightly different but near-identical spectrum of adverse events. Ibrance was the first to the market, winning FDA clearance in 2015. In 2018, Ibrance sales reached $4,118 million (90% of the market), while sales of Kisqali and Verzenio were $235 million and $255 million, respectively. The clinical and commercial success of CDK4/6 inhibitors in metastatic breast cancer have led to the enrichment of the product pipeline with the addition of many other CDK and CDK4/6 inhibitors including:

  1. Lerociclib in non-small cell lung cancer (NSCLC) and breast cancer at Phase 1/2 stage
  2. SEL24 in acute myelogenous leukemia (AML) at Phase 1/2 stage
  3. CYC065 in chronic lymphocytic leukemia (CLL) at Phase 1 stage
  4. SY-1365 in solid tumors at Phase 1 stage
  5. ON 123300 in CDK4/6 overactive tumors at pre-IND stage

Past results are discouraging.

Despite significant efforts to translate scientific knowledge into clinical development of CDK inhibitors, clinical results have been disappointing in the past. Flavopiridol, a first-generation CDK inhibitor, was investigated in more than 60 clinical trials between 1998 and 2014. Flavopiridol did not meet the initial high expectations as it showed minimal clinical benefit in patients. Despite evidence of clinical activity in haematological malignancies, such as chronic lymphocytic leukaemia (CLL, 40% response rate), Phase 3 clinical development was halted in 2012 based on lack of durable response and high disease burden in patients.

The second-generation CDK inhibitors, e.g. AZD5438, have also been extensively studied in the clinic. The efforts to achieve increasing potency and selectivity did not meet expectations. As such, development of second generation CDK inhibitors was terminated. Experts believe the failure of these drugs in the clinic could be due to the following:

  1. Lack of full understanding of the mechanism of action
  2. Poor selective targeting of CDK isoforms
  3. Inappropriate patient selection
  4. Lack of differentiation between healthy and cancerous tissues

Overall positive outlook for CDK inhibitors.

Fundamentally, the cell cycle process and cyclin-dependent kinases (CDKs) are critical regulators of cell replication, migration of survival. Deeper understanding of the biology of CDKs has been instrumental to the development of more potent CDK inhibitors, particularly in regard to determining biomarker and combination strategies. The key points to success include:

  1. specificity of the inhibitors in vivo and in vitro
  2. selection of patients
  3. selection of effective combinational strategies

 

Given the critical roles that CDKs play in multiple aspects of cell biology, CDKs inhibitors as a drug class is perceived as significant cancer therapeutics. The positive clinical data and commercial success of dual CDK4 and CDK6 inhibitors suggest that these candidate medicines could potentially be efficacious in many cancer indications.


Sources:

Asghar et al. “The history and future of targeting cyclin-dependent kinases in cancer therapy” Nat Rev Drug Discov. 2015 February; 14(2): 130–146

Besson et al. “CDK Inhibitors: Cell Cycle Regulators and BeyondDev Cell. 2008 Feb;14(2):159-69

Ameratunga et al. “To cycle or fight - CDK 4/6 inhibitors at the crossroads of anti-cancer immunity” Clinical Cancer Research 2018

www.biomedtracker.com

U.S. Food & Drug Administration


Company Ticker Price Previous Mkt Cap Volume 52wk Range
Onconova Therapeutics Inc.
ONTX (Nasdaq)
$0.83
$0.50 (+65.50%)
$153.51M
0
$0.20 - $1.56
Fundamental Analysis
Rating Outperform
Syros Pharmaceuticals Inc.
SYRS (NGS)
$10.13
$10.73 (-5.59%)
$568.53M
0
$4.27 - $15.65
Cyclacel Pharmaceuticals Inc.
CYCC (Nasdaq)
$7.74
$7.97 (-2.89%)
$37.65M
0
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  Carbon-Free Nuclear Energy Expectations Through 2050, 07/07/2020
  Energy Sector in Rapidly Growing Indonesia, 07/06/2020
  Covid-19, Scary vs. Dangerous, 07/05/2020
  Amazon Prime Video’s Move To Go Linear, 07/02/2020
  More Accurate than Polls to Gauge Election Outcomes, 07/01/2020
  Virtual Roadshows Are the New Normal, 07/01/2020
  Raw Materials and the Scalability of Tesla’s Vision, 06/29/2020
  Copying the Brightest Investment Ideas, 06/28/2020
  The Next Round of Stimulus and Industries Impacted, 06/26/2020
  Onconova Therapeutics Announces Participation In Noble Capital Markets Investor Webinar, 06/24/2020
  Virtual Power Plants and Tesla Car Batteries, 06/22/2020
  Will There be an Explosion of New Acquisitions?, 06/20/2020
  Sierra Metals Confirms New High-Grade Silver Zone At Its Cusi Mine, Mexico, Including 17 Meters True-Width Of 428 Grams Per Ton Silver, And Provides An Operational Update, 06/19/2020
  Weaning America Off Unemployment Insurance, 06/19/2020
  Is Elon Musk’s “Battery Day” Losing its Charge?, 06/17/2020
  The Limits of Government Economic Tinkering, 06/13/2020
  Gold is the New Green, 06/12/2020
  Are Individual Investors The “Smart Money”, 06/10/2020
  Restaurants Post-Lockdown Look Good!, 06/09/2020
  Genprex Scheduled to Join Russell 3000 Index, 06/09/2020
  Channelchek Virtual Road Show Series, 06/08/2020
  Channelchek C-Suite Interview Series, 06/08/2020
  Alternative Investments and 401(k) Plans, 06/06/2020
  The Supply of Cash and Stock Prices, 06/05/2020
  Should The Stock Market Be Up Double-Digits On The Year?, 06/04/2020
  Today's Feature, 05/31/2020
  Which Major Index Outperforms in June?, 05/29/2020
  Ceapro Inc. Reports 2020 First Quarter Financial Results and Highlights, 05/28/2020
  Trading Technology Continues to Level the Playing Field for Investors, 05/28/2020
  How Do Negative Interest Rates Impact Households?, 05/22/2020
  The New Age of Investor Relations, 05/21/2020
  Lower Multiples are a Good Case for Utility Investing, 05/21/2020
  The Russell Index Reconstitution, What we Expect, 05/20/2020
  Millennials Could Use Help With Investing, 05/15/2020
  The Fed’s Power and Impact are Again Tested, 05/14/2020
  Feds Bond ETF Purchases will Impact Equity Investors, 05/12/2020
  Berkshire Hathaway 2020 Annual Meeting Full Transcript and Video, 05/08/2020
  Climbing a “Wall of Worry”, 05/07/2020
  The Correlation of Passive Ownership and Underperformance, 05/05/2020
  Ely Gold Royalties Announces CAN$10,000,000 Brokered Private Placement, 05/04/2020
  Gaining More Clarity and Broadening Investment Options, 05/01/2020
  “Words of Wisdom” Awaited - Berkshire Hathaway Annual Meeting, 04/30/2020
  Small-Cap vs. Large-Cap Investing , 04/29/2020
  Companies Developing a Treatment for COVID-19 , 04/28/2020
  Covid-19 Vaccination Update, 04/24/2020
  Contango and the Known Risk to ETFs, 04/24/2020
  Investors should look beyond the headline but be aware of the bigger implications, 04/23/2020
  What Now? Post-Pandemic Stock Market Investing, 04/22/2020
  Noble Capital Markets Analyst Profile - Naureen Quibria, Ph.D., 04/20/2020
  Why Index Funds Could be a Mistake in 2020, 04/20/2020
  Noble Capital Markets Analyst Profile - Poe Fratt, 04/20/2020
  Noble Capital Markets Analyst Profile - Michael Heim, 04/20/2020
  Noble Capital Markets Analyst Profile - Joe Gomes, 04/20/2020
  Noble Capital Markets Analyst Profile - Mark Reichman, 04/20/2020
  Noble Capital Markets Analyst Profile - Michael Kupinski, 04/20/2020
  Noble Capital Markets Analyst Profile - Ahu Demir, Ph.D., 04/20/2020
  Michael Burry says COVID-19 Cure Worse than the Disease, 04/17/2020
  Has the Race for a Treatment Been Won?, 04/17/2020
  Stock Index Adjustments and Self-Directed Investors, 04/16/2020
  Ceapro Inc. Reports Fourth Quarter and Full Year 2019 Results and Highlights, 04/16/2020
  PDS Biotechnology Initiates Novel Vaccine Development Programs For COVID-19 and Universal Influenza; Delay of PDS0101 VERSATILE-002 trial, 04/16/2020
  Lowering Economic activity and Trickle Down, 04/09/2020
  Rearview Mirror Measurements in Economics, 04/09/2020
  The Case for Silver, 04/08/2020
  Should Economic Aid Target Businesses or Individuals and Families?, 04/07/2020
  Where Investors Found Double-Digit Growth in Q1, 04/03/2020
  Should Equity Markets Close for the Pandemic?, 04/03/2020
  Unemployment – how high can it go?, 04/01/2020
  Is There a Gold Lining Among These Clouds?, 03/31/2020
  A Significant Indicator of the Fed’s Resolve, 03/27/2020
  Xenetic Biosciences, Inc. Reports 2019 Year End Results and Provides Corporate Update, 03/27/2020
  Curbside Financial Advisors, 03/27/2020
  Denominators, Disease and Death, 03/26/2020
  How Your Business Can Satisfying the Current Need for Content, 03/24/2020
  COVID-19 Spread and Threat, 03/23/2020
  Capitalism Versus Coronavirus, 03/20/2020
  COVID-19, Where we are Right Now, 03/20/2020
  Factors to Consider when Setting a New Investment Course, 03/20/2020
  Here’s Your Stimulus Check, Now What?, 03/18/2020
  Portfolio Diversification May Reduce Volatility and Enhance Investment Returns , 03/17/2020
  ZIRP (Zero Interest Rate Policy) and QE5, 03/16/2020
  Bear Market Cycles, Is it “Different” this Time?, 03/13/2020
  Where Do Americans get Information for their Biggest Decisions?, 03/11/2020
  Is This the Bottom of the Barrel?, 03/10/2020
  Do Market Scares Provide Uncommon Opportunity?, 03/10/2020
  Does the Fed Have the Tools to Beat Forecasted Weakness, 03/06/2020
  Additional Balance in 60-40 Asset Mixes, 03/06/2020
  Why Gold Could Retain its Luster , 03/05/2020
  Market Selloffs and IRA Contributions , 03/02/2020
  The Business of Mass-Producing Vaccines, 03/02/2020
  Will the Stock Market Survive COVID-19, 02/26/2020
  Opportunity Zone Investment Funds Provide a Triple Tax Break, 02/25/2020
  Noble Capital Markets 2020 Investor Conference - a Huge Success, 02/20/2020
  Is the Market Disregarding Earnings Results?, 02/14/2020
  Renaissance in Inflammasome Therapeutics , 02/14/2020
  Free Markets, National Security, Global Competition, and 5G, 02/13/2020
  Valentine’s Day by the Numbers, 02/13/2020
  What Investors Should Know About Cannabis Stocks in 2020, 02/07/2020
  Containing Coronavirus has Caused an “Oil Demand Shock” , 02/05/2020
  Thirty-Something Homeownership has Declined, Have Millennials Given Up?, 02/03/2020
  The Investor Conference at the Guitar Hotel in Florida offers More than New Ideas, 01/31/2020
  The Quick Spread of Coronavirus is Impacting Global Economies and Markets , 01/29/2020
  Impact Investing Challenges Traditional Methods for Promoting Social Good, 01/27/2020
  Fin Tech is one of the Fastest Growing Tech Sectors, 01/22/2020
  Do Budget Deficits Matter? U.S. Deficit Tops $1 Trillion in First 11 Months of Fiscal Year, 01/17/2020
  Jeb Bush to Present at NobleCon16 Investor Conference , 01/17/2020
  Investment Barriers Once Seen as Insurmountable are Falling Fast, 01/17/2020
  Cobalt and Rare Earth Metals from the Ocean floor Eyed to Meet Growing Battery Demand, 01/14/2020
  Whatever Happened to the Appalachia Shale Gas Boom?, 01/13/2020
  Is a Cure for Type 1 Diabetes Imminent?, 01/10/2020
  Ari Fleischer to Present at NobleCon16 Investor Conference, 01/08/2020
  Long Term Investors and Small Cap Stocks, 01/07/2020
  Can Algorithmic Trading Continue to Expand?, 01/06/2020
  How Investment Professionals are Preparing for the New Decade, 12/31/2019
  Tech stocks were big winners in 2019 - Where to invest money in 2020?, 12/30/2019
  Cryptocurrency and the Howey Test: Are They Securities?, 12/26/2019
  Can KLK7 be used to treat skin inflammation?, 12/26/2019
  Happy Holidays, 12/24/2019
  Space Force Will Require Emerging Technologies, Emerging Growth Companies in Various Sectors may Soar, 12/23/2019
  Are Dual-Class Stocks a Mistake for Investors?, 12/20/2019
  Improving Economy with Production Cuts are Pushing Oil Prices Higher, 12/19/2019
  Should the SEC Relax Requirements for Accredited Investors? , 12/17/2019
  Putting the “Supplemental” Back into Non-GAAP Disclosures , 12/16/2019
  Aramco Goes Public in the Same Week Chevron Announces a Large Write Down, 12/16/2019
  Red-hot Biotech Stocks Boosting Small Cap Index, 12/13/2019
  Finding a Cure for AIDS Part II (Dec. 2019), 12/12/2019
  Does Santa’s Early Arrival Mean Retailers will have a Merry Christmas?, 12/11/2019
  Should Online Retailers Open Neighborhood Shops?, 12/09/2019
  Should Government Limit the Export of Fossil Fuels?, 12/06/2019
  New Era of Gene Therapy , 12/04/2019
  Can Modern Monetary Theory Work?, 12/04/2019
  Is Tesla’s Cybertruck a Turkey?, 11/27/2019
  The “Pilgrims” of Today, 11/27/2019
  Should Investors be Wary of the Companies Raising Dividends?, 11/25/2019
  Is Company Sponsored Research the Future for Small-Cap Stock Investors?, 11/25/2019
  Have Active Managers Received a Bum Rap?, 11/21/2019
  The pros and cons of media consolidation, 11/20/2019
  Why are basic material industries suffering despite government help?, 11/19/2019
  In an Increasingly Mobile Society, Will Cryptocurrencies Gain More Acceptance? , 11/14/2019
  Does the recent RAS inhibitor data show that we can effectively treat RAS-related cancers?, 11/12/2019
  Are Strong Earnings a Sign that Economic Concerns are Unwarranted? , 11/05/2019
  Taking Stock of Index Funds, 11/04/2019
  Waning Stock Buybacks: Should Investors be Worried? , 10/29/2019
  Sins of Omission , 10/29/2019
  Was the US Right in Removing Troops from Syria?, 10/25/2019
  Looking for Money Growing on Trees? Try Timber., 10/22/2019
  Is Fracking Safe?, 10/22/2019
  Can Biosimilars Finally Be Successful in the US?, 10/18/2019
  Show Me the Money: Should College Athletes Play for Pay?, 10/14/2019
  Going to the Movies? A Theater or Stream?, 10/11/2019
  Are Planned Power Outages Worth the Cost? , 10/11/2019
  Investing in Microcap Biotech Stocks, Risks and Rewards, 10/09/2019
  How Long Will U.S. Petrochemical Producers Maintain Their Global Advantage?, 10/09/2019
  Who Is to Blame for the Weak Manufacturing Number and the Market Crash? , 10/08/2019
  What’s Going on with the IPO Market?, 10/04/2019
  Smallcap Rally: Russel 2000 Trumps S&P 500 in September , 09/25/2019
  Will New 2020 Climate Change Policies Affect the Market? , 09/25/2019
  Cut to the Chase: The Reality of Rate Cuts, 09/24/2019
  Boeing 737 MAX: What’s Taking So Long?, 09/24/2019
  Silver Still has a Place on the Winners’ Podium, 09/23/2019
  Noble Capital Markets Supports Bahamas Relief Fund Through its NobleCon Investor Conference, 09/23/2019
  Can Smallcap Funds Help Cap Index Overlap in Your Portfolio? , 09/20/2019
  Is the US Accelerating toward Becoming the World’s Energy Capital? , 09/20/2019
  Attack on Saudi Refinery: What Does it Mean for You, the Investor?, 09/19/2019
  Investing in Cannabis: Should You Go Green? , 09/19/2019
  Offshore Wind Power Blows into the Energy Market, 09/18/2019
  Directed Energy Weapons: Star Wars Redux?, 09/18/2019
  Scotiabank supports young Canadians with a $500,000 donation to the Terry Fox PROFYLE program, 09/18/2019
  How Will the Authorization of AB5 Impact Gig Economies?, 09/17/2019
  Will the Market Surpass All-Time Highs? , 09/17/2019
  Onconova Therapeutics Announces Presentation on Rigosertib at the RAS-Targeted Drug Discovery Summit, 09/16/2019
  ProMIS Neurosciences Executive Chairman Eugene Williams to Speak on Panel at Fall Investor Summit, 09/16/2019
  Will the Oil Slowdown Provoke a Renewable Energy Takeover?, 09/13/2019
  Taking the FDA shortcut, 09/12/2019
  Are Nanocap Stocks a Beneficial Addition to Your Portfolio?, 09/11/2019
  Hurricanes Do More Damage than What’s on the Surface , 09/11/2019
  Independent Researchers Find Genprex's TUSC2 Prevents Tumor Growth in Triple-Negative Breast Cancer, 09/11/2019
  How Can Innovations in Transportation and Logistics Provide Value to Investors?, 09/10/2019
  Cyclical Economic Shifts: Industrial Companies Could Feel the Effects, 09/10/2019
  Will the Longest Economic Expansion in History Continue? , 09/09/2019
  Can Investing in Natural Resources Provide Future Value?, 09/06/2019
  Will Renewable Energy be the Downfall of Fossil Fuels? , 09/06/2019
  Are the Trade Troubles Coming to an End?, 09/05/2019
  Prescription Drug Pricing: How Would Limited Government Intervention Change the Landscape? , 09/05/2019
  Dyadic to Present at Janney Healthcare Conference, 09/04/2019
  Everything from A-to-Z: There are Consumer Cyclical Stocks for Everyone , 09/04/2019
  Utility Stocks May Offer Low-Risk Investment Potential, 09/04/2019
  Genprex Provides Forward Looking Guidance and Updates on Corporate Activities, Publishes New Corporate Deck, 09/03/2019
  ProMIS Neurosciences to Present at HC Wainwright Investment Conference, 09/03/2019
  Treasure hunt? Let’s Talk Silver, 09/03/2019
  Will the Slowing in Quarter 3 Affect Microcap Stocks? , 08/30/2019
  Worth the Risk? An Overview of Investing in Small & Microcap Stocks. , 08/30/2019
  How can Blockchain Help Accelerate the Agriculture Industry?, 08/30/2019
  Are Shipping Stocks Shipwrecked by the U.S. and China Disputes?, 08/29/2019
  How Will Rising Trade Tensions Impact the Aerospace Industry? , 08/29/2019
  Pharma Mergers and Acquisitions: Who’s Really Winning Here?, 08/27/2019
  Will the Uncertain Economy Boost Mining Stocks? , 08/27/2019
  Trovagene Presents Positive Clinical Data from Ongoing Phase 2 Study of Onvansertib in Metastatic Castration-Resistant Prostate Cancer (mCRPC), 08/26/2019
  What If Yields Turn Negative?, 08/26/2019
  Will Iran Continue to Grow Their Nuclear Program? , 08/22/2019
  Aurania Refines Its Newly Discovered Apai Gold-Silver Target in Southeastern Ecuador, 08/22/2019
  The inverted yield curve: what does this really indicate? , 08/21/2019
  Can Germany Survive the Trade War?, 08/21/2019
  Microsoft Acquires PromoteIQ in an attempt to compete with Amazon, 08/20/2019
  Can Blockchain Revolutionize the Banking Industry?, 08/19/2019
  Growing Industry: What Should We Look For?, 08/19/2019
  Too Busy to Shop? The Rise of Meal Kit Delivery Services, 08/15/2019
  Will owning an Electric Vehicle finally be convenient? , 08/15/2019
  Can consumers positively impact the current economic outlook?, 08/15/2019
  Can Hong Kong Retain Its Autonomy?, 08/13/2019
  FEATURE: Research | NobleCon | Podcast, 08/12/2019
  China currency devaluation: Who is this helping?, 08/12/2019
  Markets see a slight calm: how long will this last?, 08/08/2019
  Bull or bear dollar in the near future?, 08/07/2019
  Is Solar Energy the Way of the Future?, 08/05/2019
  What’s the deal with CBD?, 08/05/2019
  How far will plant-based foods go?, 08/02/2019
  What Are the Dangers of the Capital One Data Breach? , 08/02/2019
  CAR-T Cancer Treatment: Part 3, When Breakthroughs Converge, 07/31/2019
  U.S. second quarter labor costs increases by the smallest amount in 1 ½ years, 07/31/2019
  Moderate Increase in U.S. Prices and Consumer Spending, 07/30/2019
  Tensions Rise on First Federal Reserve Rate Cut in a Decade, 07/30/2019
  Is The IRS Cracking Down On Cryptocurrency? , 07/29/2019
  eSports- The Next Big Thing?, 07/25/2019
  Can Micro-Mobility Solve Last-mile Transportation Issues?, 07/24/2019
  Regulatory Overstep? How will MiFID II impact financial markets?, 07/24/2019
  Is the transportation sector signaling the next recession?, 07/23/2019
  Cryptocurrency Controversy? Facebook Reveals Libra. , 07/22/2019
  Deepfakes: Has Artificial Intelligence Gone Too Far?, 07/18/2019
  Media Quarterly Review Q2 2019, 07/18/2019
  What’s Up Next for Blockchain?, 07/16/2019
  Metals And Mining Quarterly Review Q2 2019, 07/16/2019
  Energy Quarterly Review Q2 2019, 07/16/2019
  The Controversial Question: Would You Answer It?, 07/15/2019
  Can These Tech Unicorn Companies Prove Their Worth?, 07/12/2019
  News - Are Driverless Vehicles Being Over-Hyped?, 07/10/2019
  News - Mission (Im)possible: (Un)druggable RAS?, 07/09/2019
  Fed Rate Cut: Who Does it Affect?, 07/08/2019
  Exploring a New Frontier: 5G Networking, 07/05/2019
  Big Tech Headed For A Big Breakup? FAANG, 07/02/2019
  Peace At Last? U.S.-China Announce Trade Truce, 07/01/2019
  News - Wind Energy: Is it efficient enough?, 06/25/2019
  News - CFA, CFP, CPA, CAIA, ChFC, CIPM, OMG when will it end?, 06/21/2019
  FEATURE: NobleCon 16 | Tanker Attack | Research | Podcast, 06/20/2019
  News - A Chimera for the Treatment of Cancer (Part 2), 06/20/2019
  News - What will the Persian Gulf attack mean for oil prices?, 06/17/2019
  Noble Capital Markets’ sixteenth annual investor conference, 06/14/2019
  News - A Chimera Becomes a Novel Cancer Treatment (Part 1), 06/06/2019
  News - Tariffs Make a Run for the Border, 06/04/2019
  News - The Great Debate: Active or Passive Management?, 05/30/2019
  News - Will electric cars stall the demand for oil?, 05/28/2019
  News - Videogames: The Next Professional Sport, 05/22/2019
  News - Will Green Dreams Turn Into Coal’s Nightmare?, 05/13/2019
  News - Cell Cycle Regulators as Cancer Therapeutics, 05/08/2019
  News - Game of Thrones: Energy Battles, 05/03/2019
  News - Tax Cuts and Jobs Act: Are we better off?, 04/26/2019
  News - Blockchain for Business: Worth the Hype?, 04/25/2019
  News - Uranium Imports: Trade War Goes Nuclear, 04/22/2019
  News - Does A 70% Top Marginal Tax Rate Make Sense?, 04/18/2019
  News - Boeing 737 MAX: Is it safe to fly? , 04/17/2019
  News - Could renewables supply 50% of all generation? How about 80%?, 04/05/2019
  News - Stock Buybacks: Good, evil, or maybe something in between?, 04/03/2019
  News - Macular Edema: The search for the cure continues, 04/02/2019
  News - The Case for Dr. Copper: New Sources of Demand are Positive for Copper, 03/25/2019
  News - Artificial Intelligence: Can an algorithm do what you do?, 03/14/2019
  News - CRISPR-Cas9: Editing away sickness, 03/13/2019
  News - Green New Deal: Environment Savior or Economy Destroyer?, 03/08/2019
  News - Do We Need to Prepare for War in Space?, 03/07/2019
  News - DNA Data Storage: The Future of Informatics, 03/06/2019
  News - Merger Mania Hits the Mining Space, 03/01/2019
  News - Electric Cars: Time to plug in?, 02/28/2019
  News - Could the US Have More Oil than the Saudis?!, 02/27/2019
  News - Cannabiz: Growing Like a Weed, 02/26/2019
  News - Legalizing Sports Gambling: Place Your Bets, 02/25/2019
  News - Alzheimer’s, Cannibals, and the Scientist Who Saw the Connection, 02/22/2019
  News - High-yield bonds: Trash or Treasure?, 02/13/2019
  News - Trump vs Obama: Who did the first two years better?, 02/12/2019
  WORTH READING - Electric Cars, OPEC Today, FED Impact, 02/11/2019
  Channelchek in Forbes - referenced as a gatekeeper for emerging growth companies, 02/11/2019
  News - The Great Wall of America, 01/24/2019
  News - Is OPEC still king of oil?, 01/24/2019
  News - End of an Era: Sears Struggles to Survive, 01/23/2019
  News - Buybacks: Who benefits?, 01/21/2019
  News - Robinhood: Could it steal customers from the banks?, 12/31/2018
  News - Holiday Havoc: Why December turned into a tough time for investors, 12/27/2018
  News - The Fed raised its rates, now what?, 12/19/2018
  News - Polo-like kinases inhibitors are novel drug targets of cancer therapeutics, 12/14/2018
  News - Can manufacturing keep up with demand for biologic drugs?, 12/04/2018
  News - HIV - Could there be a cure?, 12/01/2018
  News - Gold - Trending Up?, 11/27/2018
  Welcome to Channelchek video, 11/20/2018
  News - Cancer - Harnessing the power of immune system, 11/15/2018
  News - Cancer - Gene therapy, what the future holds, 11/15/2018
  News - Alzheimer’s - The race to a better treatment, 11/15/2018
  News - Trump – Is he right to withdraw from INF?, 11/15/2018
RESEARCH Reports
  Industry Report - Energy - 2020-4Q Review and Outlook, 01/05/2021
  Ayala Pharmaceuticals (AYLA) - Pivotal Desmoid Tumor Trial is Set to Initiate in H1 2021, 01/05/2021
  Gevo, Inc. (GEVO) - Two milestones in a week - FEED Engineering firm identified, 01/05/2021
  Vectrus (VEC) - A Busy Holiday Period for Vectrus Another Acquisition, 01/05/2021
  Industry Report - Metals and Mining Fourth Quarter 2020 Review and Outlook, 01/04/2021
  Helix Biopharma (HBPCF)(HBP:CA) - Q1 F2021 Business Update, 01/04/2021
  Tribune Publishing Company (TPCO) - Are You Serious?, 01/04/2021
  Gevo, Inc. (GEVO) - Debt free with higher pro forma cash balance moving into 2021, 12/31/2020
  Vectrus (VEC) - Another Major Win: OMDAC-SWACA Award, 12/31/2020
  Indonesia Energy Corp (INDO) - Shares surge 47 percent on rising oil prices, 12/31/2020
  Eagle Bulk Shipping (EGLE) - Another Ultramax Acquisition Adds to Fleet Renewal, 12/30/2020
  Vectrus (VEC) - Zenetex Acquisition Expands and Deepens Offerings, 12/30/2020
  Genco Shipping & Trading Limited (GNK) - Asset Swap Enhances Fleet Profile Without Capital Outlay, 12/29/2020
  CoreCivic, Inc. (CXW) - Sale of 42 Non-Core Properties Yields $27 million for Debt Reduction, 12/24/2020
  Eagle Bulk Shipping (EGLE) - Fleet Renewal Continues and Equity Offering Completed, 12/24/2020
  Ely Gold Royalties (ELYGF)(ELY:CA) - The Company You Keep, 12/23/2020
  Gevo, Inc. (GEVO) - Greenfield Site Announced - Debt Free One Way or Another, 12/22/2020
  Golden Predator Mining (NTGSF)(GPY:CA) - Waiting for the Bankable Feasibility Study?, 12/22/2020
  Onconova Therapeutics Inc. (ONTX) - Phase 1 Trial Commencement for CDK4 6 ARK5 Program in H1 2021, Rating Raised, 12/22/2020
  Schwazze (SHWZ) - Half A Hit Is Better Than No Hit At All Closes On Six Star Buds Locations, 12/22/2020
  Euroseas Ltd. (ESEA) - Another Fixture Beats Expectations on Rate and Term, 12/22/2020
  Genprex (GNPX) - REQORSA Manufacturing is Scaled Up for Clinical Testing, 12/22/2020
  Gevo, Inc. (GEVO) - More Clarity on First Project. Debt Free Heading into 2021, 12/21/2020
  Coeur Mining (CDE) - The Story Is Growing Stronger, 12/18/2020
  enCore Energy Corp. (ENCUF)(EU:CA) - Coverage Initiated As Outperform to Ride Uranium Price Wave, 12/18/2020
  Orion Group Holdings (ORN) - Two Marine Awards for $20 million. Program Sales Initiated, 12/18/2020
  Eagle Bulk Shipping (EGLE) - Shifting to Growth?, 12/17/2020
  Esports Entertainment Group, Inc. (GMBL) - Acquisition Improves Its Hand, 12/17/2020
  Energy Services of America (ESOA) - Acquisition Adds Confidence to FY2021 Outlook, 12/17/2020
  Gray Television Inc. (GTN) - A Peachy Political Outlook, 12/17/2020
  Tribune Publishing Company (TPCO) - Building A Large Cash Hoard, 12/17/2020
  Townsquare Media Inc (TSQ) - Why We Are Raising Estimates And Price Target?, 12/16/2020
  Allegiant Gold Ltd (AUXXF) - Fashioning Nevada's Eastside Project Into A Multi-Million Ounce Gold Resource, 12/15/2020
  Ely Gold Royalties (ELYGF)(ELY:CA) - Executes Option Agreement to Sell Weepah Closes Acquisition of Watershed Royalty, 12/15/2020
  Energy Fuels (UUUU)(EFR:CA) - Line of Sight Toward Commercial Mixed REE Production Investor Webcast on December 15, 12/15/2020
  Energy Services of America (ESOA) - PPP tax payment masks strong quarter and profitable year, 12/14/2020
  FAT Brands Inc. (FAT) - FAT Brands, Fog Cutter Merger Announced Increasing PT, 12/14/2020
  Aurania Resources (AUIAF)(ARU:CA) - Solid Progress, 12/11/2020
  Indonesia Energy Corp (INDO) - Delay to Drilling Start May Be a Good Thing With Rising Oil Prices, 12/11/2020
  Great Lakes Dredge & Dock (GLDD) - Cant Win Them All - Houston Move Creates Some Turnover, 12/10/2020
  Comtech Telecommunications Corporation (CMTL) - 1Q Results Beat Expectations But COVID Impacts Continue, 12/10/2020
  Kratos Defense & Security (KTOS) - $37.7 million Skyborg Award, 12/09/2020
  DLH Holdings Corp. (DLHC) - Covid Continues to Impact Revenues But Well Positioned Going Forward, 12/08/2020
  Palladium One Mining Inc. (NKORF)(PDM:CA) - Tyko Nickel Project Drilling Program Yields Success, 12/08/2020
  Great Lakes Dredge and Dock (GLDD) - Offshore Wind Plans Drive Expansion of Fleet Renewal, 12/07/2020
  Schwazze (SHWZ) Historic - Vote, But What Does it Mean?, 12/07/2020
  Vectrus (VEC) - New Business Momentum Continuing, 12/07/2020
  Ayala Pharmaceuticals (AYLA) - Top NOTCH Targeting for Broad Oncology Indications, Initiating Coverage at Outperform, 12/02/2020
  Newrange Gold (NRGOF)(NRG:CA) - Recent Drilling Reveals a New Gold Zone at Pamlico, 12/02/2020
  Euroseas Ltd. (ESEA) - Higher Rates on New Fixtures Boost EBITDA Estimates, 12/01/2020
  Gevo, Inc. (GEVO) - Upcoming Milestones - Increasing Price Target, 11/30/2020
  Aurania Resources (AUIAF)(ARU:CA) - Work Advances at Tsenken Investor Call Scheduled for December 1st, 11/27/2020
  Comtech Telecommunications Corporation (CMTL) - Another Major NG911 Win, 11/25/2020
  Kelly Services Inc. (KELYA) - Expands Into Higher Education with Acquisition of Greenwood Asher Associates, 11/25/2020
  Schwazze (SHWZ) - Schwazze: Building a Seed to Sale Colorado Powerhouse, 11/24/2020
  Euroseas (ESEA) - Soft 3Q2020 But Container Market Fundamentals Improving, 11/23/2020
  Pyxis Tankers Inc. (PXS) - Lowering EBITDA Estimate to Reflect 3Q2020 and Soft Outlook, 11/23/2020
  When Will Western Canadian Oil Producers Improve Cash Flow?, 11/23/2020
  Esports Entertainment Group, Inc. (GMBL) - Heightened M&A Activity In The Gambling Space Validates ESports Strategy, 11/20/2020
  Great Lakes Dredge & Dock (GLDD) - Largest Award Ever On Horizon, 11/19/2020
  Lineage Cell Therapeutics (LCTX) - Takeaways from Expert call on OpRegen, 11/19/2020
  Palladium One Mining Inc. (NKORF)(PDM:CA) - Another Important Element to the Story, 11/19/2020
  Seanergy Maritime (SHIP) - Improved Quarter, But Refinancing Risk Remains High, 11/19/2020
  Esports Entertainment Group, Inc. (GMBL) - Building a Sturdy Foundation Esports Business, 11/18/2020
  Seanergy Maritime (SHIP) - Upcoming 3Q2020 Call Will Focus on Dry Bulk Market and Debt Refinancing, 11/18/2020
  Comstock Mining (LODE) - Solid Execution, 11/18/2020
  Cocrystal Pharma Inc. (COCP) - Q3 EPS Pipeline Remains on Track, 11/17/2020
  EuroDry Ltd. (EDRY) - A Solid Quarter - Looking Ahead to 2021, 11/17/2020
  electroCore, Inc (ECOR) - 3Q Cost reduced Revenue Generation Continues, 11/16/2020
  Golden Predator Mining (NTGSF)(GPY:CA) - 2020 Drilling Program Completed Assay Results Pending, 11/16/2020
  InPlay Oil (IPOOF)(IPO:CA) - The road to normal, 11/16/2020
  Newrange Gold (NRGOF)(NRG:CA) - Drilling Pauses to Allow for Receipt and Analysis of Assay Results, 11/16/2020
  Pangaea Logistics Solutions Ltd. (PANL) - Surprising Reaction to 3Q2020 Results, 11/16/2020
  Dyadic International Inc. (DYAI) - Q3 EPS: More to come over the next 12 months, 11/13/2020
  One Stop Systems Inc. (OSS) - 3Q Results Exceed Expectations, 11/13/2020
  PDS Biotechnology Corp (PDSB) - 3Q Update: Phase 2 Study in Head and Neck Cancer is Initiated, 11/13/2020
  Salem Media (SALM) - A Nice Political Boost; Raising Estimates, 11/13/2020
  Harte-Hanks Inc. (HRTH) - A Nice Upside Surprise; Raise Full Year Estimates, 11/13/2020
  QuoteMedia (QMCI) - Improving Revenue Picture; Raising Price Target, 11/13/2020
  Onconova Therapeutics Inc. (ONTX) - Q3 Overview: Phase 1 Entry of CDK4 6 ARK5 Program, 11/13/2020
  FAT Brands Inc. (FAT) - Good Results Tempered by COVID Johnny Rockets to Impact Fourth Quarter, 11/12/2020
  ACCO Brands Corporation (ACCO) - PowerA Acquisition Expands Consumer Offerings, 11/11/2020
  Gevo Inc. (GEVO) - 3Q2020 Capital Raises Enhance Funding Visibility and Project Financing Discussions Progressing, 11/11/2020
  Palladium One Mining Inc. (NKORF)(PDM:CA) - Building Scale at the Palladium-Dominant LK Project, 11/11/2020
  Vectrus (VEC) - After a 3Q Beat, What's Next?, 11/11/2020
  Sierra Metals (SMTS)(SMT:CA) - Big 3Q Beat; Raising Estimates, 11/10/2020
  Townsquare Media Inc (TSQ) - An Impressive Recovery; Raising Estimates, 11/10/2020
  Information Services (III) - Beats 3Q Expectations, Continues to Move Forward in a COVID World, 11/10/2020
  E.W. Scripps Company (SSP) - A Political Firestorm, 11/10/2020
  Orion Group Holdings (ORN) - New Concrete awards positive - Asset sales look likely, 11/10/2020
  CoreCivic (CXW) - Post Call Commentary Updated Model and Thoughts on Biden Presidency, 11/09/2020
  Eagle Bulk Shipping (EGLE) - Turning Point? 4Q2020 Off to Solid Start, 11/09/2020
  Neovasc (NVCN)(NVCN:CA) - Q3 Earnings: Reducer Commercialization in the US is Delayed, 11/09/2020
  TherapeuticsMD (TXMD) - Q3 EPS: Annovera Sales Impress, 11/09/2020
  Endeavour Silver (EXK)(EDR:CA) - Turning the Corner, 11/06/2020
  Genco Shipping & Trading Limited (GNK) - Turning More Favorable - Introducing 2021 EBITDA Estimate, 11/06/2020
  Kelly Services Inc. (KELYA) - Better Than Expected 3Q EPS But End Markets Remain Fluid, 11/06/2020
  Cumulus Media Inc. (CMLS) - Improving Revenue Trends Nice Liquidity, 11/06/2020
  Entravision Communications Corporation (EVC) - An Ugly Duckling Digital Biz Turns Into A Swan Price Target Raised, 11/06/2020
  Gray Television Inc. (GTN) - Georgia Is On Its Mind For an Extraordinary Political Year, 11/06/2020
  Tribune Publishing Company (TPCO) - Raising Estimates And Our Price Target, 11/05/2020
  Aurania Resources (AUIAF)(ARU:CA) - Aurania Provides Update on Drilling Program Closes Equity Financing, 11/05/2020
  CoreCivic (CXW) - Reports Solid Third Quarter, 11/05/2020
  Energy Fuels (UUUU)(EFR:CA) - Moving from Concept to Reality, 11/05/2020
  Great Lakes Dredge & Dock (GLDD) - Another Good Quarter - Execution Remains Solid, 11/05/2020
  Lineage Cell Therapeutics (LCTX) - Q3 2020 Earnings OpRegen Data Update at AAO, 11/05/2020
  Ely Gold Royalties (ELYGF)(ELY:CA) - ELY Consolidates Railroad-Pinion Royalties in Nevada's Carlin Trend, 11/03/2020
  InPlay Oil (IPOOF)(IPO:CA) - IPO finalize lending facility, announces small tuck-in acquisition, details 4Q cap spend, 11/03/2020
  Energy Fuels (UUUU)(EFR:CA) - Modestly Wider Loss Than Expected; Webcast on November 3, 11/02/2020
  Orion Group Holdings (ORN) - Introducing 2021 EBITDA Estimate and Raising Price Target, 11/02/2020
  Coeur Mining (CDE) - Soaring Past Third Quarter Expectations, 10/30/2020
  The GEO Group, Inc. (GEO) - Another Solid Quarter in the Face of Covid Challenges, 10/30/2020
  Kratos Defense And Security (KTOS) - Momentum Continues to Build; Exceeds 3Q Consensus Estimates, 10/30/2020
  1-800-Flowers.com (FLWS) - Another Quarter Of Enhanced Growth; Raising Target, 10/30/2020
  ACCO Brands Corporation (ACCO) - Post Call Commentary and Updated Models, 10/29/2020
  Newrange Gold (NRGOF)(NRG:CA) - Will Drilling at Good Hope Represent an Inflection Point?, 10/29/2020
  Orion Group Holdings (ORN) - Another Strong Quarter - Concrete Pours It In, 10/29/2020
  ACCO Brands Corporation (ACCO) - A Third Quarter Beat, 10/28/2020
  Esports Entertainment Group, Inc. (GMBL) - Initiating Coverage: A Stake In Fast Growing Esports, 10/28/2020
  Orion Group Holdings (ORN) - 3Q2020 Preview - Progress Looks On Track, 10/27/2020
  Palladium One Mining Inc. (NKORF)(PDM:CA) - Right Metals, Right Time, Right Jurisdictions, 10/27/2020
  Ceapro (CRPOF)(CZO:CA) - NRC Grant to Produce Coronavirus Therapeutic Candidates by PGX Technology, 10/23/2020
  Neovasc (NVCN)(NVCN:CA) - The FDA Panel to Decide on Reducer Commercialization in the US, 10/22/2020
  Travelzoo (TZOO) - Moving Along The Road To Recovery, 10/22/2020
  E.W. Scripps Company (SSP) - A Legacy Of Creating Value, 10/21/2020
  Newrange Gold (NRGOF)(NRG:CA) - Drilling Commences at Gold Box Canyon, 10/20/2020
  Seanergy Maritime (SHIP) - Fine tuning 2020 EBITDA Estimate, 10/16/2020
  Entravision Communications Corporation (EVC) - Accelerates Its Digital Advertising Transition, 10/16/2020
  Sierra Metals (SMTS)(SMT:CA) - Better-Than-Expected Third Quarter Production; Increasing Estimates, 10/15/2020
  Ely Gold Royalties (ELYGF)(ELY:CA) - Deliberate Addition to ELY's Growing Nevada Royalty Portfolio, 10/14/2020
  Endeavour Silver (EXK)(EDR:CA) - Making Good Progress, 10/14/2020
  Lineage Cell Therapeutics (LCTX) - Early VAC2 Data Shows Promise, 10/14/2020
  FAT Brands Inc. (FAT) - Upgrading to Outperform with $8 Price Target, 10/12/2020
  Industry Report - Media - Quarterly Review: Has The Market Already Factored In The Elections?, 10/12/2020
  DLH Holdings Corp. (DLHC) - Post IBA Acquisition Call Commentary, 10/09/2020
  Comstock Mining (LODE) - Mercury Remediation Pilot Program Commences at American Flat, 10/09/2020
  Ely Gold Royalties (ELYGF)(ELY:CA) - Executes Option Agreement to Sell Aurora West Property to Goldcliff Resources, 10/09/2020
  Comtech Telecommunications Corporation (CMTL) - Implications of a Terminated Merger, 10/06/2020
  PDS Biotechnology Corp (PDSB) - PDS's Diverse Portfolio in Broad Therapeutic Areas Is Highly Appealing, 10/06/2020
  Industry Report - Metals and Mining Third Quarter Review and Outlook, 10/05/2020
  Great Lakes Dredge & Dock (GLDD) - New Announcements Push 3Q2020 Awards to $417 Million, 10/05/2020
  Industry Report - Energy - Exploration and Production: 2020-3Q Review and Outlook, 10/02/2020
  DLH Holdings Corp. (DLHC) - What Does the New Acquisition Bring?, 10/02/2020
  Comtech Telecommunications Corporation (CMTL) - Solid End to the Year in an Uncertain Environment, 10/01/2020
  Kratos Defense & Security (KTOS) - Contract Momentum - Part 2, 10/01/2020
  Energy Fuels (UUUU)(EFR:CA) - Executive Order Aims to Reduce Reliance on Critical Minerals from Foreign Adversaries, 10/01/2020
  Ely Gold Royalties (ELYGF)(ELY:CA) - Purchase of Royalty Would Provide Exposure to Cote Gold Project in Ontario, 09/30/2020
  Indonesia Energy Corp (INDO) - INDO reports 1H Financials. Drilling delayed but story still intact, 09/30/2020
  Golden Predator Mining (NTGSF)(GPY:CA) - Drilling Program Begins; Feasibility Study Expected in Q1-21, 09/29/2020
  Kratos Defense & Security (KTOS) - Recent Award Momentum, 09/29/2020
  Pangaea Logistics Solutions Ltd. (PANL) - JV Interest Acquisition Enhances Fleet Profile, 09/29/2020
  Orion Group Holdings (ORN) - Low Bid Awarded and Limited Work Disruptions, 09/29/2020
  Aurania Resources (AUIAF)(ARU:CA) - Tiria-Shimpia Emerges As a High Priority Epithermal Target, 09/28/2020
  Great Lakes Dredge & Dock (GLDD) - Impressive Quarter. 3Q2020 Awards to Date Total $428 million, 09/25/2020
  E.W. Scripps Company (SSP) - Ion Media Acquisition; Positively Viewed, 09/25/2020
  Great Lakes Dredge & Dock (GLDD) - A Victory on Jacksonville C, 09/24/2020
  Townsquare Media Inc (TSQ) - Revenues Trending Better Than Expected, 09/23/2020
  Energy Fuels (UUUU)(EFR:CA) - UUUU to Participate in Government Funded Rare Earths Initiative, 09/22/2020
  Euroseas Ltd. (ESEA) - Higher Rates on New Charter and Scrapping Announced, 09/22/2020
  Newrange Gold (NRGOF)(NRG:CA) - Moving Up the Learning Curve, 09/22/2020
  Industry Report - Metals and Mining Insights from the Precious Metals Summit, 09/21/2020
  Onconova Therapeutics (ONTX) - CDK4/6 Program Advances into Clinic in China, 09/21/2020
  Great Lakes Dredge & Dock (GLDD) - Low Bids Become Awards of $119 million. More Awards Ahead, 09/17/2020
  Lineage Cell Therapeutics (LCTX) - Initiating Coverage, Eye of Stem Cell Treatments and Beyond, 09/17/2020
  CoreCivic (CXW) - A Quick Turnaround for Cimarron Facility, 09/16/2020
  Vectrus (VEC) - New Contract Award, 09/16/2020
  Comstock Mining (LODE) - Completes Sale of Lucerne While Retaining Economic Exposure, 09/15/2020
  Eagle Bulk Shipping (EGLE) - CEO Interview Highlights Active Management Strategy and Fleet Renewal Program, 09/15/2020
  Coeur Mining (CDE) - Increasing Estimates; Upgrading to Outperform, 09/14/2020
  Gevo, Inc. (GEVO) - Virtual Roadshow Should Highlight Improved Visibility, 09/14/2020
  Travelzoo (TZOO) - Initiating Coverage; A Compelling Play On The Travel Industry Recovery, 09/14/2020
  Great Lakes Dredge & Dock (GLDD) - New Low Bids Pending Award Should Boost Backlog, 09/14/2020
  Comstock Mining (LODE) - Pelen Purchase Option Could Enhance LODE's Growing Royalty Portfolio, 09/10/2020
  E.W. Scripps Company (SSP) - Why We Are Raising Cash Flow Estimates & Price Target, 09/09/2020
  Cocrystal Pharma Inc. (COCP) - The High Unmet Need Persists in Influenza, 09/03/2020
  Ely Gold Royalties (ELYGF)(ELY:CA) - Poised to Broaden Its Horizon?, 09/02/2020
  Newrange Gold (NRGOF)(NRG:CA) - Next Wave of Pamlico Drilling Results Expected Shortly, 09/02/2020
  Golden Predator Mining (NTGSF) - Updated Technical Report Provides Solid Foundation for Advancing to a Feasibility Study, 09/01/2020
  Grindrod Shipping (GRIN) - Better Than Expected 1H2020 Results. Firmer 2H2020 Outlook., 08/31/2020
  1-800-Flowers.com (FLWS) - Long Legs in E-Commerce Trends; Raising Price Target, 08/28/2020
  DLH Holdings Corp. (DLHC) - A Significant Renewal, 08/27/2020
  Comstock Mining (LODE) - Taking a Methodical Approach Toward Advancing Dayton and Spring Valley, 08/27/2020
  Gevo, Inc. (GEVO) - ATM Offering and Warrant Exercises Add Almost $60 Million, 08/26/2020
  Kelly Services Inc. (KELYA) - Are the B Shares Telling Us Something?, 08/25/2020
  Aurania Resources (AUIAF)(ARU:CA) - Near-Term Focus Turns to Copper, 08/24/2020
  Gevo, Inc. (GEVO) - ATM Offering of $50 million Removes Funding Overhang, 08/24/2020
  Orion Group Holdings (ORN) - Corpus Christi Accident Late Last Week, 08/24/2020
  Onconova Therapeutics (ONTX) - INSPIRE Fails, What is Next for Onconova?, 08/24/2020
  Gevo, Inc. (GEVO) - Supply Portfolio Doubles and Industry Player Added, 08/21/2020
  Great Lakes Dredge & Dock (GLDD) - New and upcoming awards support 2H2020 backlog rebound, 08/21/2020
  Seanergy Maritime (SHIP) - Equity Offering Surprising; Lowering Rating to Market Perform, 08/19/2020
  Comstock Mining (LODE) - Laying the Groundwork for Growing Shareholder Value, 08/18/2020
  Energy Services of America (ESOA) - In Line Quarter. Signs of Recovery Ahead., 08/18/2020
  Euroseas Ltd. (ESEA) - Insurance Claim Boosts 2Q2020 Results. Container Rates Soft, But Signs of Improvement Emerging, 08/17/2020
  InPlay Oil (IPOOF)(IPO:CA) - Better-than-expected results and new credit facility may mean stock has bottomed out, 08/17/2020
  Sierra Metals (SMTS)(SMT:CA) - Better-Than-Expected Second Quarter; Increasing Estimates, 08/17/2020
  Dyadic International Inc. (DYAI) - Q2 EPS: Making Progress with C1 Technology, 08/14/2020
  FAT Brands Inc. (FAT) - A Rocketship of an Acquisition, 08/14/2020
  Harte-Hanks Inc. (HRTH) - Recovering Better Than Expected, 08/14/2020
  Pangaea Logistics (PANL) - Unique Business Model Delivers Strong Operating Results in Challenging Times, 08/14/2020
  CoreCivic (CXW) - Deeper Dive into 2Q Results and C-Corp Announcement, 08/13/2020
  Onconova Therapeutics Inc. (ONTX) - Q2 EPS: Can't-Wait to INSPIRE, 08/13/2020
  QuoteMedia (QMCI) - Keeping The Foot On The Pedal, 08/13/2020
  Cumulus Media Inc. (CMLS) - Planned Asset Sales Enhance Investment Appeal, 08/12/2020
  Ely Gold Royalties (ELYGF)(ELY:CA) - Expands Nevada Portfolio with Acquisition of Three Royalties, 08/12/2020
  Kelly Services Inc. (KELYA) - What Did The JOLTS Report Say?, 08/12/2020
  Pyxis Tankers Inc. (PXS) - In Line Quarter. Waiting for Seasonal Upswing, 08/12/2020
  Vectrus (VEC) - Working Through COVID, 08/12/2020
  EuroDry Ltd. (EDRY) - 2Q2020 Shortfall Impacts 2020 EBITDA Estimate, But Firmer Dry Bulk Market Drives 2H2020 Rebound, 08/11/2020
  Gevo, Inc. (GEVO) - Quarterly Loss Narrows After Cost Cuts. Capital Raise Creates Near-term Cash Cushion, 08/11/2020
  Information Services (III) - Better Than Expected 2Q20 Performance, 08/11/2020
  Townsquare Media Inc (TSQ) - Reaffirms Its Favorable Digital Revenue Outlook, 08/11/2020
  One Stop Systems Inc. (OSS) - Better Than Expected 2Q20 Results, 08/10/2020
  Kelly Services Inc. (KELYA) - How Does COVID Impact the Rest of the Year?, 08/10/2020
  The GEO Group, Inc. (GEO) - Retaining REIT Status, but Cutting Dividend, Focus on Reducing Debt, 08/10/2020
  Gray Television Inc. (GTN) - Outshining Many Of Its Peers, 08/10/2020
  E.W. Scripps (SSP) - Dish, The Dirt On The Quarter, 08/10/2020
  Neovasc (NVCN) (NVCN:CA) - Q2 EPS Preview: Lots of Near-Term Catalysts, 08/10/2020
  Eagle Bulk Shipping (EGLE) - A Tough Quarter But Better Times Ahead, 08/10/2020
  Cocrystal Pharma Inc. (COCP) - Q2 EPS: Transformational 12 Months Ahead, 08/07/2020
  DLH Holdings (DLHC) - Post 3Q Call Commentary: Company Well Positioned to Capitalize on Current Trends, 08/07/2020
  FAT Brands Inc. (FAT) - What Has Been the COVID Impact?, 08/07/2020
  Genco Shipping (GNK) - Is the Dry Bulk Market Weakness in the Rear View Mirror?, 08/07/2020
  Salem Media (SALM) - Overachieves Cash Flow Expectations; Raising Estimates, 08/07/2020
  Aurania Resources (AUIAF) - Kirus is Starting to Look a Lot Like Tsenken, 08/07/2020
  CoreCivic (CXW) - Ditching REIT Status; 2Q Results In-Line, 08/06/2020
  DLH Holdings (DLHC) - 3Q Revenues Light, But EPS On Target, 08/06/2020
  Seanergy Maritime (SHIP) - 2Q2020 Loss Reflects Weak Dry Bulk Market, But 2H2020 Recovery Appears Under Way., 08/06/2020
  Tribune Publishing (TPCO) - Are The Shares Too Cheap To Ignore?, 08/06/2020
  Cocrystal Pharma Inc. (COCP) - Promising Preclinical Data from Coronavirus Program, 08/05/2020
  Endeavour Silver (EXK) - Better Than Expected 2Q Results; Increasing 2021 Estimates, 08/05/2020
  Great Lakes Dredge & Dock (GLDD) - A Solid Quarter in COVID-19 Era; Increasing Price Target, 08/05/2020