Movers and SHAKERS
Dyadic International Inc. (DYAI)
Step Closer to Generating Human-like Proteins with C1 Platform
Dyadic International, Inc. is a global biotechnology company which is developing what it believes will be a potentially significant biopharmaceutical gene expression platform based on the industrially proven hyper productive engineered fungus Thermothelomyces heterothallica (formerly Myceliophthora thermophila), named C1.
The C1 microorganism, which enables the development and large scale manufacture of low cost proteins, has the potential to be further developed into a safe and efficient expression system that may help speed up the development, lower production costs and improve the performance of biologic vaccines and drugs at flexible commercial scales. Dyadic is using the C1 technology and other technologies to conduct research, development and commercial activities for the development and manufacturing of human and animal vaccines and drugs, such as virus like particles (VLPs) and antigens, monoclonal antibodies, Fab antibody fragments, Fc-Fusion proteins, biosimilars and/or biobetters, and other therapeutic proteins. Dyadic pursues research and development collaborations, licensing arrangements and other commercial opportunities with its partners and collaborators to leverage the value and benefits of these technologies in development and manufacture of biopharmaceuticals. In particular, as the aging population grows in developed and undeveloped countries, Dyadic believes the C1 technology may help bring biologic vaccines, drugs and other biologic products to market faster, in greater volumes, at lower cost, and with new properties to drug developers and manufacturers, and improve access and cost to patients and the healthcare system, but most importantly save lives.
Ahu Demir, Ph.D., Biotechnology Research Analyst, Noble Capital Markets, Inc.
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A building block for human glycan is produced by the C1 platform. Dyadic’s research partner VTT Technical Research Centre of Finland (VTT) presented data showing expression of the building block (G0 glycan) of human-like glycoproteins (at 94% relative expression). We think this is a key milestone for the company to validate the C1 platform in bioproduction.
Expressing human-like proteins is insight. Glycoproteins, such as monoclonal antibodies, are proteins that have sugars (glycans) attached to them. The majority (over 50%) of the biologics, sales of which are expected to grow to 300 billion by 2022, are glycoproteins. Glycoengineering is crucial in drug development, as glycans have marked effects on stability, activity, antigenicity, and...
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