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Caladrius Biosciences Inc.
NobleCon16
Cornerstone Capital Resources Inc.
NobleCon16
Abacus Health Products Inc.
NobleCon16
Assure Holdings
NobleCon16
Ballard Power Systems Inc.
NobleCon16
Duos Technologies Group Inc
NobleCon16
Pyxis Tankers Inc.
NobleCon16
Capstone Turbine Corporation
NobleCon16
Avino Silver & Gold Mines Ltd. (Canada)
NobleCon16
Hoth Therapeutics Inc.
NobleCon16
PDS Biotechnology Corporation
NobleCon16
Comstock Mining Inc.
NobleCon16
Cocrystal Pharma Inc.
NobleCon16
Lightwave Logic Inc
NobleCon16
Energy Fuels Inc
NobleCon16
Pangaea Logistics Solutions Ltd.
NobleCon16
Comtech Telecommunications Corp.
NobleCon16
Sernova Corp
NobleCon16
Orion Group Holdings Inc. Common
NobleCon16
Sundance Energy Inc. - Ordinary Shares
NobleCon16
AgEagle Aerial Systems Inc.
NobleCon16
Exactus Inc
NobleCon16
Gray Television Inc.
NobleCon16
Xenetic Biosciences Inc.
NobleCon16
Gevo Inc.
NobleCon16
Newrange Gold Corp.
NobleCon16
Sierra Metals Inc.
NobleCon16
Summit Wireless Technologies Inc.
NobleCon16
Empire Diversified Energy Inc
NobleCon16
OncoSec Medical Incorporated
NobleCon16
Progressive Care Inc
NobleCon16
Lineage Cell Therapeutics, Inc.
NobleCon16
InPlay Oil Corp.
NobleCon16
Tonix Pharmaceuticals Holding Corp.
NobleCon16
Helix Biopharma Corp
NobleCon16
Brainstorm Cell Therapeutics Inc.
NobleCon16
Ely Gold Royalties Inc.
NobleCon16
Endeavour Silver Corporation (Canada)
NobleCon16
Information Services Group Inc.
NobleCon16
Educational Development Corporation
NobleCon16
Aeterna Zentaris Inc.
NobleCon16
Applied Energetics Inc
NobleCon16
Great Panther Mining Limited (Canada)
NobleCon16
Acco Brands Corporation
NobleCon16
Golden Valley Mines Ltd
NobleCon16
Matinas Biopharma Holdings Inc.
NobleCon16
Seanergy Maritime Holdings Corp
NobleCon16
International Seaways Inc.
NobleCon16
Onconova Therapeutics Inc.
NobleCon16
EuroDry Ltd.
NobleCon16
Imagin Medical Inc
NobleCon16
ProMIS Neurosciences Inc.
NobleCon16
Salarius Pharmaceuticals
NobleCon16
SRAX
NobleCon16
Exro Technologies Inc - Ordinary Shares
NobleCon16
Euroseas Ltd.
NobleCon16
Ocugen, Inc.
NobleCon16
Tower One Wireless Corp
NobleCon16
Kelly Services Inc. Class A Common Stock
NobleCon16
Tribune Publishing Company
NobleCon16
Silver One Resources Inc.
NobleCon16
Genprex Inc.
NobleCon16
Citius Pharmaceuticals Inc.
NobleCon16
electroCore Inc.
NobleCon16
Salem Media Group Inc.
NobleCon16
Eagle Bulk Shipping Inc.
NobleCon16
Qualstar Corporation
NobleCon16
Indonesia Energy Corp Ltd - Ordinary Shares
NobleCon16
Ceapro Inc
NobleCon16
Freedom Holding Corp - Ordinary Shares
NobleCon16
Lumina Gold Corp.
NobleCon16
Dyadic International Inc.
NobleCon16
Interpace Diagnostics Group Inc.
NobleCon16
1-800 FLOWERS.COM Inc.
NobleCon16
Entravision Communications Corporation
NobleCon16
TrovaGene Inc.
NobleCon16
SPI Energy Co. Ltd.
NobleCon16
Townsquare Media Inc. Class A
2019 Radio Show: Bill Wilson Opening
Enochian Biosciences Inc.
Introduction
Actinium Pharmaceuticals Inc. (Delaware)
Actinium Pharmaceuticals at NobleConXV
QuoteMedia Inc.
NobleCon XV
Aurania Resources Ltd.
NobleConXV
Information Services Group Inc.
NobleConXV
Salem Media Group Inc.
NobleConXV
The KEYW Holding Corporation
NobleConXV
Townsquare Media Inc. Class A
NobleConXV
Tribune Publishing Company
NobleConXV
Salem Media Group Inc.
Salem Media Group at NobleCon
TrovaGene Inc.
TrovaGene Inc at NobleConXV
Genie Energy Ltd. Class B Stock
NobleConXV
Pyxis Tankers Inc.
Pyxis Tankers Inc. at NobleConXV
Pangaea Logistics Solutions Ltd.
Pangaea Logistics Solutions Ltd. at NobleConXV
One Stop Systems Inc.
NobleConXV
Seanergy Maritime Holdings Corp
Seanergy Maritime Holdings at NobleConXV
Great Panther Mining Limited (Canada)
Great Panther Silver at NobleConXV
Great Lakes Dredge & Dock Corporation
Great Lakes Dredge & Dock Corporation at NobleConXV
Genco Shipping & Trading Limited New (Marshall Islands)
Genco Shipping & Trading Limited at NobleConXV
Endeavour Silver Corporation (Canada)
Endeavour Silver Corporation at NobleConXV
Eagle Bulk Shipping Inc.
Eagle Bulk Shipping at NobleConXV
Brainstorm Cell Therapeutics Inc.
BrainStorm Cell Therapeutics at NobleConXV
Dyadic International Inc.
Dyadic International at NobleConXV
Arcadia Biosciences Inc.
Arcadia Biosciences Inc at NobleConXV
Comtech Telecommunications Corp.
Comtech Telecommunications Corp. at NobleConXV
Torchlight Energy Resources Inc.
Torchlight Energy Resources, Inc. at NobleConXV
electroCore Inc.
NobleConXV
Altimmune Inc.
Altimmune Inc at NobleConXV
Sierra Metals Inc.
Sierra Metals Inc. at NobleConXV
IEC Electronics
IEC Electronics at NobleConXV
COVID-19 Spread and Threat
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Could a Natural Mutation Slowdown COVID-19?

(Note: companies that could be impacted by the content of this article are listed at the base of the story [desktop version]. This article uses third-party references to provide a bullish, bearish, and balanced point of view; sources are listed after the Balanced section.)

“The single biggest threat to man’s continued dominance on the planet is the virus”,

quote by Joshua Lederberg (see photograph below).

The best medical scientists, physicians, epidemiologists, microbiologists, and infectious disease experts are currently joining forces worldwide to find a way to stop the spreading of SARS-CoV-2, the coronavirus causing “Coronavirus Disease of 2019” (Covid-19), which has become a global pandemic. As of March 22, 2020, there are more than 335,400 people infected with SARS-CoV-2 worldwide, and more than 14,610 people have died from the disease.

Figure 1 – Structure of the new coronavirus, SARS-CoV-2, images by transmission electron microscopy. The virus resembles an sphere with spikes. The S-protein or Spike protein is critical for virus entry into human cells.

A picture containing indoor, sitting, old, photo

Description automatically generated

Source – Science 2020, 367 (6483) p1260-1263

As the biotechnology/pharmaceutical industry collaborates with medical academic institutions in the search for a treatment/vaccine or cure for Covid-19, it is difficult to predict the evolution of the current pandemic and virus behavior in coming weeks, months. As the world waits for the outcome of ongoing clinical trials evaluating potential treatments for Covid-19, it is important keeping aware of what medical science has taught us from previous epidemics such as SARS in 2002, middle east respiratory outbreak (MERS) in 2012 and Spanish flu (1918). Despite of the relatively short history of Covid-19, which started in China in December 2019, knowledge of the biology of the new coronavirus, SARSCoV-2, have grown very quickly.

New Discoveries Could Speed up Vaccine Development

Recently, scientists at the University of Texas, Austin, discovered the mechanism of entry of SARS-CoV-2 into human cells (Science 2020, 367 (6483) p1260-1263). The Spike protein, or S-protein, is critical for viral entry. Another group of researchers led by Qiang Zhou, a research fellow at Westlake University in Hangzhou, China, have revealed how the new virus attaches to a receptor on respiratory cells called “angiotensin-converting enzyme 2”, or ACE2 ( Science March 4th, 2020: eabb2762 DOI: 10.1126/science.abb2762). Zhou and his team have now discovered the second part of the puzzle by describing how S-protein binds to ACE2 receptor on the surface of respiratory cells. This knowledge could be critical for the success of ongoing efforts to find a treatment or cure.

Figure 2 – Mechanism of entry of SARS-CoV-2 into human cells. The virus mechanism of entry is similar to the one utilized by the virus SARS-CoV, which caused the SARS outbreak of 2002. Panel A depicts “Spike protein” or “S-protein” on the surface of the coronavirus binding to “angiotensin-converting enzyme 2” (ACE-2) receptors on the surface of a human cell. Panel B shows the “type II transmembrane serine protease” (TMPRSS2) binding to and cleaving ACE-2 receptor, which activates the Spike protein of the coronavirus. Panel C shows viral entry.